Phenotypes associated with this allele

• Allele Symbol: Tg(dlx5a-cre)1Mekk
• Allele Name: transgene insertion 1, Marc Ekker
• Allele ID: MGI:3758328
• Summary: 10 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Gt(ROSA)26Sor^em1(Tor1b)Wtd/Gt(ROSA)26Sor^+ Tg(dlx5a-cre)1Mekk/0	involves: 129 * C57BL/6 * CD-1	MGI:6710965
cn2	Ntrk1^tm2.1Lfr/Ntrk1^tm2.1Lfr Tg(dlx5a-cre)1Mekk/0	involves: 129 * C57BL/6 * CD-1 * SJL	MGI:5319088
cn3	Cdkl5^tm1.1Cogr/Y Tg(dlx5a-cre)1Mekk/0	involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6J * CD-1	MGI:5574068
cn4	Cdkl5^tm1.1Cogr/? Tg(dlx5a-cre)1Mekk/0	involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6J * CD-1	MGI:5574069
cn5	Mecp2^tm1Bird/Y Tg(dlx5a-cre)1Mekk/0	involves: 129P2/OlaHsd * 129S6/SvEvTac * CD-1 * FVB/N	MGI:4999644
cn6	Cnr1^tm1.2Ltz/Cnr1^tm1.2Ltz Tg(dlx5a-cre)1Mekk/?	involves: 129P2/OlaHsd * C57BL/6NCrl * CD-1	MGI:3758334
cn7	Cnr1^tm1.2Ltz/Cnr1^tm1.2Ltz Tg(dlx5a-cre)1Mekk/?	involves: 129P2/OlaHsd * CD-1	MGI:3758337
cn8	Tor1a^tm1Wtd/Tor1a^tm3.1Wtd Tg(dlx5a-cre)1Mekk/0	involves: 129S1/Sv * 129S6/SvEvTac * C57BL/6J * CD-1	MGI:6710969
cn9	Gt(ROSA)26Sor^em1(Tor1b)Wtd/Gt(ROSA)26Sor^+ Tor1a^tm1Wtd/Tor1a^tm3.1Wtd Tg(dlx5a-cre)1Mekk/0	involves: 129S1/Sv * 129S6/SvEvTac * C57BL/6J * CD-1	MGI:6710971
cn10	Crhr1^tm2Wrst/Crhr1^tm2Wrst Tg(dlx5a-cre)1Mekk/0	involves: 129S2/SvPas * C57BL/6J * CD-1	MGI:5294459

Genotype
MGI:6710965

cn1

• Allelic Composition: Gt(ROSA)26Sor^{em1(Tor1b)Wtd}/Gt(ROSA)26Sor⁺; Tg(dlx5a-cre)1Mekk/0
• Genetic Background: involves: 129 * C57BL/6 * CD-1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:288753 )

N • mice show normal postnatal growth and survival, and normal juvenile reflexes, including negative geotaxis, surface righting, and forelimb hang

Genotype
MGI:5319088

cn2

• Allelic Composition: Ntrk1^tm2.1Lfr/Ntrk1^tm2.1Lfr; Tg(dlx5a-cre)1Mekk/0
• Genetic Background: involves: 129 * C57BL/6 * CD-1 * SJL

nervous system

abnormal innervation ( J:183467 )

• impaired cholinergic innervation into the frontal cortex at P7

• decrease in cholinergic fiber density and absence of a clear laminar pattern of innervation in the hippocampus at P14

• complete absence of cholinergic fibers in the hippocampus and only a small number of fibers in the frontal cortex at P90

behavior/neurological

abnormal behavior ( J:183467 )

• measurable decline in amygdala-dependent, but not hippocampal-dependent, cognitive performance

impaired cued conditioning behavior ( J:183467 )

abnormal response to novel object ( J:183467 )

• significant decrease in recognition of a novel object

Genotype
MGI:5574068

cn3

• Allelic Composition: Cdkl5^tm1.1Cogr/Y; Tg(dlx5a-cre)1Mekk/0
• Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6J * CD-1

behavior/neurological

behavior/neurological phenotype ( J:209635 )

♂N • mice do not exhibit abnormal clasping or head tracking

Genotype
MGI:5574069

cn4

• Allelic Composition: Cdkl5^tm1.1Cogr/?; Tg(dlx5a-cre)1Mekk/0
• Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6J * CD-1

behavior/neurological

behavior/neurological phenotype ( J:209635 )

♂N • mice do not exhibit abnormal clasping or head tracking

decreased locomotor activity ( J:209635 )

♂

Genotype
MGI:4999644

cn5

• Allelic Composition: Mecp2^tm1Bird/Y; Tg(dlx5a-cre)1Mekk/0
• Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * CD-1 * FVB/N

mortality/aging

mortality/aging ( J:166851 )

♂N • mice survive to at least 80 weeks of age

behavior/neurological

behavior/neurological phenotype ( J:166851 )

♂N • mice show similar grooming times to controls

♂N • mice have a nonsignificant trend to reduced total distance traveled

♂N • time exhibiting aggressive behavior such as wrestling, tail-rattling, boxing, and mounting is similar to controls

♂N • mice exhibit intact olfactory recognition and habituation in response to a novel odorant at 11 weeks of age

♂N • at 12 weeks, mice have intact nociception demonstrated by a hot-plate or tail-flick assay

decreased startle reflex ( J:166851 )

♂ • mice show impaired maximum acoustic startle response to 120dB

impaired coordination ( J:166851 )

♂ • mice display more footslips, shorter latency to fall on wire, reduced number of side touches on dowel and shorter latency to fall from rotarod compared to controls

increased stereotypic behavior ( J:166851 )

♂ • mice show a 200% increase relative to control in number of holes explored with 2 or more sequential nose pokes in a holeboard assay

abnormal nest building behavior ( J:166851 )

♂ • nest building is impaired

abnormal social investigation ( J:166851 )

♂ • mice show increased social interaction with novel and familiar partners; time spent with novel partners is 60% higher than in controls in a 3-chamber assay

nervous system

increased prepulse inhibition ( J:166851 )

♂ • 24 week-old mice show increased prepulse inhibition at 74 dB

respiratory system

respiratory system phenotype ( J:166851 )

♂N • mice show no alterations in tidal volume or minute volume, and display no apneas

Genotype
MGI:3758334

cn6

• Allelic Composition: Cnr1^tm1.2Ltz/Cnr1^tm1.2Ltz; Tg(dlx5a-cre)1Mekk/?
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6NCrl * CD-1

nervous system

abnormal inhibitory postsynaptic currents ( J:122066 )

• depolarization-induced suppression of inhibition, as measured by evoked inhibitory postsynaptic current amplitude, is abolished

behavior/neurological

behavior/neurological phenotype ( J:122066 )

N • 30 mg/kg kainic acid induces similar seizures as in wild-type mice and diazepam protects mice and wild-type mice similarly against kainic acid-induced seizures

Genotype
MGI:3758337

cn7

• Allelic Composition: Cnr1^tm1.2Ltz/Cnr1^tm1.2Ltz; Tg(dlx5a-cre)1Mekk/?
• Genetic Background: involves: 129P2/OlaHsd * CD-1

nervous system

abnormal cerebral cortex morphology ( J:121856 )

• probability that pyramidal cells will receive VGAT+/VGLUT3+ boutons in layer 2/3 of the neocortex is increased

• however, interneuron migration and neurochemical specification are normal

Genotype
MGI:6710969

cn8

• Allelic Composition: Tor1a^tm1Wtd/Tor1a^tm3.1Wtd; Tg(dlx5a-cre)1Mekk/0
• Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * C57BL/6J * CD-1

behavior/neurological

limb grasping ( J:288753 )

• mice exhibit limb clasping in the tail suspension test at P70

trunk curl ( J:288753 )

• mice exhibit abnormal twisting movements and 9 of 11 mice show trunk twisting during the tail suspension test

nervous system

abnormal brain interneuron morphology ( J:288753 )

• mice exhibit 33.5% fewer dorsal striatal cholinergic interneurons at P70

neuron degeneration ( J:288753 )

• mice exhibit 33.5% fewer dorsal striatal cholinergic interneurons at P70, indicating degeneration

Genotype
MGI:6710971

cn9

• Allelic Composition: Gt(ROSA)26Sor^{em1(Tor1b)Wtd}/Gt(ROSA)26Sor⁺; Tor1a^tm1Wtd/Tor1a^tm3.1Wtd; Tg(dlx5a-cre)1Mekk/0
• Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * C57BL/6J * CD-1

behavior/neurological

behavior/neurological phenotype ( J:288753 )

N • mice show rescue of the limb clasping phenotype and the twisting movements seen in Tor1a^tm1Wtd/Tor1a^tm3.1Wtd Tg(Dlx5a-cre)1Mekk/0 mice

nervous system

nervous system phenotype ( J:288753 )

N • mice show prevention of striatal cholinergic interneuron degeneration that occurs in Tor1a^tm1Wtd/Tor1a^tm3.1Wtd Tg(Dlx5a-cre)1Mekk/0 mice

Genotype
MGI:5294459

cn10

• Allelic Composition: Crhr1^tm2Wrst/Crhr1^tm2Wrst; Tg(dlx5a-cre)1Mekk/0
• Genetic Background: involves: 129S2/SvPas * C57BL/6J * CD-1

behavior/neurological

behavior/neurological phenotype ( J:176339 )

N • mice exhibit normal anxiety-related behavior, forced swim test, and auditory fear conditioning

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:176339 )

N • mice exhibit normal basal and stress-induced corticosterone levels