behavior/neurological
N |
• mice show normal postnatal growth and survival, and normal juvenile reflexes, including negative geotaxis, surface righting, and forelimb hang
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Allele Symbol Allele Name Allele ID |
Tg(dlx5a-cre)1Mekk transgene insertion 1, Marc Ekker MGI:3758328 |
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Summary |
10 genotypes
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
N |
• mice show normal postnatal growth and survival, and normal juvenile reflexes, including negative geotaxis, surface righting, and forelimb hang
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• impaired cholinergic innervation into the frontal cortex at P7
• decrease in cholinergic fiber density and absence of a clear laminar pattern of innervation in the hippocampus at P14
• complete absence of cholinergic fibers in the hippocampus and only a small number of fibers in the frontal cortex at P90
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• measurable decline in amygdala-dependent, but not hippocampal-dependent, cognitive performance
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• significant decrease in recognition of a novel object
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
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• mice do not exhibit abnormal clasping or head tracking
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
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• mice do not exhibit abnormal clasping or head tracking
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
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• mice survive to at least 80 weeks of age
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• mice show similar grooming times to controls
• mice have a nonsignificant trend to reduced total distance traveled
• time exhibiting aggressive behavior such as wrestling, tail-rattling, boxing, and mounting is similar to controls
• mice exhibit intact olfactory recognition and habituation in response to a novel odorant at 11 weeks of age
• at 12 weeks, mice have intact nociception demonstrated by a hot-plate or tail-flick assay
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• mice show impaired maximum acoustic startle response to 120dB
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• mice display more footslips, shorter latency to fall on wire, reduced number of side touches on dowel and shorter latency to fall from rotarod compared to controls
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• mice show a 200% increase relative to control in number of holes explored with 2 or more sequential nose pokes in a holeboard assay
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• nest building is impaired
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• mice show increased social interaction with novel and familiar partners; time spent with novel partners is 60% higher than in controls in a 3-chamber assay
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• 24 week-old mice show increased prepulse inhibition at 74 dB
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• mice show no alterations in tidal volume or minute volume, and display no apneas
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• depolarization-induced suppression of inhibition, as measured by evoked inhibitory postsynaptic current amplitude, is abolished
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N |
• 30 mg/kg kainic acid induces similar seizures as in wild-type mice and diazepam protects mice and wild-type mice similarly against kainic acid-induced seizures
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• probability that pyramidal cells will receive VGAT+/VGLUT3+ boutons in layer 2/3 of the neocortex is increased
• however, interneuron migration and neurochemical specification are normal
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• mice exhibit limb clasping in the tail suspension test at P70
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• mice exhibit abnormal twisting movements and 9 of 11 mice show trunk twisting during the tail suspension test
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• mice exhibit 33.5% fewer dorsal striatal cholinergic interneurons at P70
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• mice exhibit 33.5% fewer dorsal striatal cholinergic interneurons at P70, indicating degeneration
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
N |
• mice show rescue of the limb clasping phenotype and the twisting movements seen in Tor1atm1Wtd/Tor1atm3.1Wtd Tg(Dlx5a-cre)1Mekk/0 mice
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N |
• mice show prevention of striatal cholinergic interneuron degeneration that occurs in Tor1atm1Wtd/Tor1atm3.1Wtd Tg(Dlx5a-cre)1Mekk/0 mice
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
N |
• mice exhibit normal anxiety-related behavior, forced swim test, and auditory fear conditioning
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N |
• mice exhibit normal basal and stress-induced corticosterone levels
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 08/02/2024 MGI 6.24 |
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