All Phenotypes Pgm3<Gt(W037B08)Wrst> MGI Mouse

postnatal lethality ( J:125094 )

• fewer than expect mice survive to weaning

abnormal spermatogenesis ( J:125094 )

• while immature spermatpgonia is detected all mature spermtocytes are pyknotic

male infertility ( J:125094 )

• irregardless of the genotype of the females, male mice never sire offspring

increased pro-B cell number ( J:125094 )

• the number of B220+ CD43+ pro-B cells are increased 2-fold relative to in wild-type mice

abnormal T cell differentiation ( J:125094 )

• mice exhibit an increase in the ratio of CD4+ to CD8+ T cells in the lymph nodes relative to wild-type mice

anemia ( J:125094 )

decreased bone marrow cell number ( J:125094 )

• bone marrow cell number is reduced to 50% of that observed in wild-type mice

decreased erythrocyte cell number ( J:125094 )

• 6.5+/-2.0 x10⁹/ml compared to 8.0+/-0.62x10⁹/ml in Pgm3^mld1 homozygotes and 10.4+/-0.5 x10⁹/ml in wild-type mice

decreased hematocrit ( J:125094 )

• 37.9+/-10.9% compared to 45.8+/-3.0% in Pgm3^mld1 homozygotes and 53.2+/-2.4% in wild-type mice

thrombocytopenia ( J:125094 )

• 858+/-312x10⁶/ml compared to 620+/-128x10⁶/ml in Pgm3^mld1 homozygotes and 1159+/-176x10⁶/ml in wild-type mice

decreased leukocyte cell number ( J:125094 )

• 4.8+/-2.1x10⁶/ml compared to 3.7+/-1.3x10⁶/ml in Pgm3^mld1 homozygotes and 9.2+/-1.9x10⁶/ml in wild-type mice

decreased B cell number ( J:125094 )

• the frequency and number of B cells at all later stages of maturation is reduced and the B cell number in the peritoneal cavity and peripheral lymphoid organs is reduced

absent follicular B cells ( J:125094 )

• lymphoid follicles are absent

decreased T cell number ( J:125094 )

• the number of T cells in the spleen is moderately to severely reduced compared to in wild-type mice

increased spleen red pulp amount ( J:125094 )

pancreatic acinar hypoplasia ( J:125094 )

• acini are reduced in size and dispersed

abnormal feces composition ( J:125094 )

• protein fecal content is increased relative to in wild-type mice

abnormal salivary gland morphology ( J:125094 )

• salivary gland architecture is disrupted

• cells are reduced in size and dispersed

glomerulonephritis ( J:125094 )

• mice exhibit glomerulonephritis with amorphous material filling the glomeruli