Phenotypes associated with this allele

• Allele Symbol: sbse
• Allele Name: small body and small ear
• Allele ID: MGI:3758823
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	sbse/sbse	C57BL/6J-sbse/GrsrJ	MGI:3767240

Genotype
MGI:3767240

hm1

• Allelic Composition: sbse/sbse
• Genetic Background: C57BL/6J-sbse/GrsrJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

craniofacial

decreased cranium height ( J:128399 )

small cranium ( J:128399 )

short mandible ( J:128399 )

short maxilla ( J:128399 )

domed cranium ( J:128399 )

short snout ( J:128399 )

small ears ( J:128399 )

skeleton

decreased cranium height ( J:128399 )

small cranium ( J:128399 )

short mandible ( J:128399 )

short maxilla ( J:128399 )

domed cranium ( J:128399 )

decreased bone mineral content ( J:128399 )

• whole body bone mineral content is decreased

decreased bone mineral density ( J:128399 )

• whole body bone mineral density is decreased

growth/size/body

short snout ( J:128399 )

small ears ( J:128399 )

decreased body size ( J:128399 )

decreased body weight ( J:128399 )

• weight of homozygotes at ages 4, 8, 12, and 16 weeks is approximately 70% that of heterozygous controls

hearing/vestibular/ear

small ears ( J:128399 )

increased or absent threshold for auditory brainstem response ( J:128399 )

• at 7 weeks of age homozygotes have an ABR threshold about 20 db higher than controls, and at 3 months of age it is 30 db higher

increased susceptibility to age-related hearing loss ( J:128399 )

reproductive system

decreased litter size ( J:128399 )

• homozygous females bred with heterozygous males have an average litter size of 4.3 pups, while heterozygous females bred with heterozygous or homozygous males have an average litter size of 5.4 pups

nervous system

hydrocephaly ( J:128399 )

adipose tissue

decreased percent body fat/body weight ( J:128399 )

• PIXImus densitometry shows decreased whole body fat

endocrine/exocrine glands

endocrine/exocrine gland phenotype ( J:128399 )

N • pituitary assessment found no abnormalities

vision/eye

vision/eye phenotype ( J:128399 )

N • eyes are normal by ophthalmoscopic examination at 4 weeks of age