Phenotypes associated with this allele

• Allele Symbol: Tg(TcrLCMV)2Aox
• Allele Name: transgene insertion 2, Annette Oxenius
• Allele ID: MGI:3758830
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
tg1	Tg(TcrLCMV)2Aox/?	C57BL/6-Tg(TcrLCMV)2Aox	MGI:3758831

Genotype
MGI:3758831

tg1

• Allelic Composition: Tg(TcrLCMV)2Aox/?
• Genetic Background: C57BL/6-Tg(TcrLCMV)2Aox

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

increased double-negative T cell number ( J:92228 )

decreased double-positive T cell number ( J:92228 )

• virtual absence of double positive cells

increased CD4-positive, alpha-beta T cell number ( J:92228 )

• the number of CD4+CD8- cells is increased

• more than 90% of peripheral CD4+ T cells express transgene

• the ratio of CD4+ to CD8+ T cells is 6:1 compared to 1.8:1 in wild-type mice

decreased CD8-positive, alpha-beta T cell number ( J:92228 )

• the number of CD4-CD8+ cells is decreased

abnormal cytotoxic T cell physiology ( J:92228 )

• reduced cytotoxic T cell response

hematopoietic system

increased double-negative T cell number ( J:92228 )

decreased double-positive T cell number ( J:92228 )

• virtual absence of double positive cells

increased CD4-positive, alpha-beta T cell number ( J:92228 )

• the number of CD4+CD8- cells is increased

• more than 90% of peripheral CD4+ T cells express transgene

• the ratio of CD4+ to CD8+ T cells is 6:1 compared to 1.8:1 in wild-type mice

decreased CD8-positive, alpha-beta T cell number ( J:92228 )

• the number of CD4-CD8+ cells is decreased

abnormal cytotoxic T cell physiology ( J:92228 )

• reduced cytotoxic T cell response