All Phenotypes Ripply2<tm1.1Ysa> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Ripply2^tm1.1Ysa
targeted mutation 1, Yumiko Saga
MGI:3758856

Summary

5 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ripply2^tm1.1Ysa/Ripply2^tm1.1Ysa	involves: C57BL/6 * CBA	MGI:4459315
hm2	Ripply2^tm1.1Ysa/Ripply2^tm1.1Ysa	involves: C57BL/6 * CBA * ICR	MGI:3758869
cx3	Ripply1^tm1.1Sjt/Ripply1^tm1.1Sjt Ripply2^tm1.1Ysa/Ripply2^tm1.1Ysa	involves: 129S1/Sv * C57BL/6 * CBA * FVB/N	MGI:4459313
cx4	Ripply1^tm1.1Sjt/Y Ripply2^tm1.1Ysa/Ripply2^tm1.1Ysa	involves: 129S1/Sv * C57BL/6 * CBA * FVB/N	MGI:4459314
cx5	Lfng^tm1Rjo/Lfng^tm1Rjo Ripply2^tm1.1Ysa/Ripply2^tm1.1Ysa	involves: 129S7/SvEvBrd * C57BL/6 * CBA * ICR	MGI:3758871

Allelic Composition	Ripply2^tm1.1Ysa/Ripply2^tm1.1Ysa
Genetic Background	involves: C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ripply2^tm1.1Ysa mutation (1 available); any Ripply2 mutation (15 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

skeleton

abnormal vertebrae morphology ( J:161418 )

• mice exhibit rostralization of vertebrae compared with wild-type mice

abnormal vertebral pedicle morphology ( J:161418 )

• mice exhibit partial pedicle of the neural arches and separated lamina unlike wild-type mice

Allelic Composition	Ripply2^tm1.1Ysa/Ripply2^tm1.1Ysa
Genetic Background	involves: C57BL/6 * CBA * ICR

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ripply2^tm1.1Ysa mutation (1 available); any Ripply2 mutation (15 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:123846 )

• homozygotes die shortly after birth

embryo

failure of somite differentiation ( J:123846 )

• at E17.5, embryos have not undergone normal somitogenesis and display no clear segmental borders

growth/size/body

decreased body length ( J:123846 )

• at E17.5, embryos have short trunks

limbs/digits/tail

short tail ( J:123846 )

• at E17.5, embryos have short tails

skeleton

absent proximal rib ( J:123846 )

• at E17.5, embryos lack components of the proximal ribs

absent vertebral pedicles ( J:123846 )

• at E17.5, embryos show fewer pedicles of the neural arches

muscle

abnormal myotome morphology ( J:123846 )

• at E17.5, embryos have irregularly sized myotomes

Allelic Composition	Ripply1^tm1.1Sjt/Ripply1^tm1.1Sjt Ripply2^tm1.1Ysa/Ripply2^tm1.1Ysa
Genetic Background	involves: 129S1/Sv * C57BL/6 * CBA * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ripply1^tm1.1Sjt mutation (0 available); any Ripply1 mutation (11 available)
Ripply2^tm1.1Ysa mutation (1 available); any Ripply2 mutation (15 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

skeleton

abnormal vertebrae morphology ( J:161418 )

• mice exhibit rostralization of vertebrae compared with wild-type mice that is enhanced compared to in Ripply2^tm1.1Ysa homozygotes

absent vertebral pedicles ( J:161418 )

• with fusion of the lamina in the vertebrae

embryo

abnormal rostral-caudal patterning of the somites ( J:161418 )

• marker expression reveals rostralization of somites compared to in wild-type mice

Allelic Composition	Ripply1^tm1.1Sjt/Y Ripply2^tm1.1Ysa/Ripply2^tm1.1Ysa
Genetic Background	involves: 129S1/Sv * C57BL/6 * CBA * FVB/N

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

skeleton

abnormal vertebrae morphology ( J:161418 )

• mice exhibit rostralization of vertebrae compared with wild-type mice that is enhanced compared to in Ripply2^tm1.1Ysa homozygotes

absent vertebral pedicles ( J:161418 )

• with fusion of the lamina in the vertebrae

embryo

abnormal rostral-caudal patterning of the somites ( J:161418 )

• marker expression reveals rostralization of somites compared to in wild-type mice

Allelic Composition	Lfng^tm1Rjo/Lfng^tm1Rjo Ripply2^tm1.1Ysa/Ripply2^tm1.1Ysa
Genetic Background	involves: 129S7/SvEvBrd * C57BL/6 * CBA * ICR

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lfng^tm1Rjo mutation (0 available); any Lfng mutation (32 available)
Ripply2^tm1.1Ysa mutation (1 available); any Ripply2 mutation (15 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

embryo

abnormal rostral-caudal axis patterning ( J:123846 )

• embryos show a more rostralized phenotype than Ripply2-null embryos

skeleton

absent vertebral pedicles ( J:123846 )

• pedicals of the neural arches are almost completely absent

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