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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Sema3ftm1Mom
targeted mutation 1, Peter Mombaerts
MGI:3758889
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
 		Sema3ftm1Mom/Sema3ftm1Mom
Vmn1r49tm1Mom/Vmn1r49tm1Mom 		involves: 129P2/OlaHsd * C57BL/6J MGI:3760745
cx2
 		Sema3ftm1Mom/Sema3f+
Vmn1r49tm1Mom/Vmn1r49tm1Mom 		involves: 129P2/OlaHsd * C57BL/6J MGI:3760746
cx3
 		Gucy2dtm1Mom/Gucy2dtm1Mom
Sema3ftm1Mom/Sema3ftm1Mom 		involves: 129P2/OlaHsd * C57BL/6J MGI:3760748


Genotype
MGI:3760745
cx1
Allelic
Composition		 Sema3ftm1Mom/Sema3ftm1Mom
Vmn1r49tm1Mom/Vmn1r49tm1Mom
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sema3ftm1Mom mutation (1 available); any Sema3f mutation (41 available)
Vmn1r49tm1Mom mutation (1 available); any Vmn1r49 mutation (27 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal accessory olfactory bulb morphology ( J:125485 )
• Npr2+ axons erroneously project into the posterior accessory olfactory bulb
• V1rb2+ axons form glomeruli in the posterior accessory olfactory bulb unlike in wild-type mice




Genotype
MGI:3760746
cx2
Allelic
Composition		 Sema3ftm1Mom/Sema3f+
Vmn1r49tm1Mom/Vmn1r49tm1Mom
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sema3ftm1Mom mutation (1 available); any Sema3f mutation (41 available)
Vmn1r49tm1Mom mutation (1 available); any Vmn1r49 mutation (27 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal accessory olfactory bulb morphology ( J:125485 )
• in 18.2% of mice, exhibit misprojections of V1rb2+ axons in the accessory olfactory bulb




Genotype
MGI:3760748
cx3
Allelic
Composition		 Gucy2dtm1Mom/Gucy2dtm1Mom
Sema3ftm1Mom/Sema3ftm1Mom
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gucy2dtm1Mom mutation (1 available); any Gucy2d mutation (43 available)
Sema3ftm1Mom mutation (1 available); any Sema3f mutation (41 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal olfactory bulb morphology ( J:125485 )
• authors state that mice exhibit the same defects as observed in Gucy2dtm1Mom Nrp2tm1.2Mom homozygotes




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory