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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Steap3fred
fragile-red
MGI:3758911
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Steap3fred/Steap3fred C57BL/6-Steap3fred MGI:3833932


Genotype
MGI:3833932
hm1
Allelic
Composition
Steap3fred/Steap3fred
Genetic
Background
C57BL/6-Steap3fred
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Steap3fred mutation (4 available); any Steap3 mutation (63 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
N
• unlike red cells, leukocyte and platelet numbers are similar to controls
• reduced mean hemoglobin level
• target cells are present
• polychromasia
• two fold reduction in ferrireductase activity in whole blood cells

homeostasis/metabolism
• decreased serum cupric levels
• total iron binding capacity is elevated almost 2 fold and saturation is similar to controls
• significantly increased in females

cardiovascular system

liver/biliary system
• significantly increased in females

reproductive system
N
• despite anemia mice are able to breed normally

immune system

growth/size/body





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory