Phenotypes associated with this allele

• Allele Symbol: Thra^tm1Ffla
• Allele Name: targeted mutation 1, Frederic Flamant
• Allele ID: MGI:3758914
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Tg(Nes-cre)1Kln/0 Thra^tm1Ffla/Thra^+	involves: 129 * C57BL/6 * SJL	MGI:6317188
cn2	Tg(CAG-cre/Esr1*)5Amc/? Thra^tm1Ffla/Thra^+	involves: 129/Sv * C57BL/6 * CBA	MGI:3758925
cn3	Thra^tm1Ffla/Thra^+ Tg(Sycp1-cre)4Min/?	involves: 129/Sv * C57BL/6 * DBA/2	MGI:3758926

Genotype
MGI:6317188

cn1

• Allelic Composition: Tg(Nes-cre)1Kln/0; Thra^tm1Ffla/Thra⁺
• Genetic Background: involves: 129 * C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, incomplete penetrance ( J:268664 )

nervous system

abnormal cerebellum morphology ( J:268664 )

Genotype
MGI:3758925

cn2

• Allelic Composition: Tg(CAG-cre/Esr1*)5Amc/?; Thra^tm1Ffla/Thra⁺
• Genetic Background: involves: 129/Sv * C57BL/6 * CBA

nervous system

abnormal cerebellum morphology ( J:125353 )

• authors state that mice treated at E17.5 with tamoxifen exhibit a phenotype similar but less severe to that observed in Thra^tm1Ffla Tg(Sycp1-cre)4Min mice

growth/size/body

abnormal postnatal growth ( J:125353 )

• authors state that mice treated at E17.5 with tamoxifen exhibit a phenotype similar but less severe to that observed in Thra^tm1Ffla Tg(Sycp1-cre)4Min mice

cardiovascular system

abnormal heart rate ( J:125353 )

• authors state that mice treated at E17.5 with tamoxifen exhibit a phenotype similar but less severe to that observed in Thra^tm1Ffla Tg(Sycp1-cre)4Min mice

skeleton

delayed bone ossification ( J:125353 )

• authors state that mice treated at E17.5 with tamoxifen exhibit a phenotype similar but less severe to that observed in Thra^tm1Ffla Tg(Sycp1-cre)4Min mice

Genotype
MGI:3758926

cn3

• Allelic Composition: Thra^tm1Ffla/Thra⁺; Tg(Sycp1-cre)4Min/?
• Genetic Background: involves: 129/Sv * C57BL/6 * DBA/2

mortality/aging

postnatal lethality, incomplete penetrance ( J:125353 )

• 48% of mice do not reach adulthood

reproductive system

female infertility ( J:125353 )

♀ • despite no obvious defects in ovary morphology, females are sterile

nervous system

abnormal cerebellum external granule cell layer morphology ( J:125353 )

• unlike in wild-type mice, at P21 the external granule layer persists and granular precursor cells are still present

abnormal Purkinje cell dendrite morphology ( J:125353 )

• at P15, arborization of Purkinje cell dendrites is reduced by number and size of dendritic spines

behavior/neurological

ataxia ( J:125353 )

• mice display an ataxic bearing and spread their hindlimbs to maintain their posture

growth/size/body

disproportionate dwarf ( J:125353 )

• while surviving mice gain weight they suffer from a permanent and disproportioned dwarfism

postnatal growth retardation ( J:125353 )

homeostasis/metabolism

impaired adaptive thermogenesis ( J:125353 )

• mice exhibit a defect in thermogenesis such that the body temperature in some mice drops within a few hours after cold exposure

cardiovascular system

increased heart rate ( J:125353 )

• 224+/-24 beats per minute compared to 393+/-45 beats per minute in wild-type mice

irregular heartbeat ( J:125353 )

• mice sometime display cardiac arrhythmia

skeleton

delayed endochondral bone ossification ( J:125353 )

• ossification of the long bones is delayed

hematopoietic system

decreased spleen weight ( J:125353 )

• at P15, spleen weight is decreased (26.9+/-12.2 mg compared to 39.5+/-9.1 mg in wild-type mice)

vision/eye

delayed eyelid opening ( J:125353 )

• eyelid opening was delayed to P25 compared to P15 in wild-type mice

immune system

decreased spleen weight ( J:125353 )

• at P15, spleen weight is decreased (26.9+/-12.2 mg compared to 39.5+/-9.1 mg in wild-type mice)