Analysis Tools
reproductive system
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• at 6 weeks of age, male homozygotes show a severe reduction in the number of spermatocytes relative to wild-type mice
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• mutant testes show absence of postmeitotic germ cells
• meiosis is decreased, especially at the stages of pachytene and beyond
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• at ~P17, early spermatocytes begin to undergo morphological changes indicative of cell death
• by P22, advanced pachytene spermatocytes exhibit increased levels of apoptosis, as revealed by TUNEL analysis
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small testis
(
J:125346
)
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• adult male homozygotes exhibit smaller testes than wild-type or heterozygous controls
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• at 6 weeks of age, mutant testes are one third the weight of testes in wild-type mice
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• matings of homozygous mutant males with wild type females do not produce any offspring
• in contrast, female homozygotes are fertile with no apparent ovarian defects
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endocrine/exocrine glands
small testis
(
J:125346
)
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• adult male homozygotes exhibit smaller testes than wild-type or heterozygous controls
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• at 6 weeks of age, mutant testes are one third the weight of testes in wild-type mice
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cellular
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• at 6 weeks of age, male homozygotes show a severe reduction in the number of spermatocytes relative to wild-type mice
|
|
|
• mutant testes show absence of postmeitotic germ cells
• meiosis is decreased, especially at the stages of pachytene and beyond
|
|
|
• at ~P17, early spermatocytes begin to undergo morphological changes indicative of cell death
• by P22, advanced pachytene spermatocytes exhibit increased levels of apoptosis, as revealed by TUNEL analysis
|
