Phenotypes associated with this allele

• Allele Symbol: Cdk11b^Gt(XG836)Byg
• Allele Name: gene trap XG836, BayGenomics
• Allele ID: MGI:3759055
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cdk11b^Gt(XG836)Byg/Cdk11b^Gt(XG836)Byg	involves: 129P2/OlaHsd * C57BL/6J	MGI:3759057

Genotype
MGI:3759057

hm1

• Allelic Composition: Cdk11b^Gt(XG836)Byg/Cdk11b^Gt(XG836)Byg
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased skin papilloma incidence ( J:125424 )

• one mouse treated with acetone in 7,12-dimethylbenz[a]anthracene (DMBA) developed 4 papilomas of greater than 1 mm³ at week 14

• however, mice treated with TPA in DMBA develop skin papillomas at the same rate of latency and incidence as wild-type mice

• at week 19 of treated with 12-O-tetradecanoylphorbol-13-acetate (TPA) in DMBA, mice exhibit an increase of 2.7-fold in the average number of papillomas and the number of papillomas per mouse compared to similarly treated wild-type mice

• mice treated with TPA in DMEA exhibit a higher frequency of larger tumors (1 to 5 and greater than 5 mm³) compared to similarly treated wild-type mice (1.2 and 1.4 compared to 0.6 and 0.6)

integument

abnormal skin morphology ( J:125424 )

• proliferation in the skin is increased relative to in wild-type mice

thick epidermis ( J:125424 )

• in mice either treated with acetone in 7,12-dimethylbenz[a]anthracene (DMBA) or 12-O-tetradecanoylphorbol-13-acetate (TPA) in DMBA, epidermal thickness is increased (26.17+/-24.03 um and 84.86+/-42.53 um, respectively, compared to 10.0+/-0.00 um and 62.73+/-35.97 um, respectively, in wild-type mice)

increased skin papilloma incidence ( J:125424 )

• one mouse treated with acetone in 7,12-dimethylbenz[a]anthracene (DMBA) developed 4 papilomas of greater than 1 mm³ at week 14

• however, mice treated with TPA in DMBA develop skin papillomas at the same rate of latency and incidence as wild-type mice

• at week 19 of treated with 12-O-tetradecanoylphorbol-13-acetate (TPA) in DMBA, mice exhibit an increase of 2.7-fold in the average number of papillomas and the number of papillomas per mouse compared to similarly treated wild-type mice

• mice treated with TPA in DMEA exhibit a higher frequency of larger tumors (1 to 5 and greater than 5 mm³) compared to similarly treated wild-type mice (1.2 and 1.4 compared to 0.6 and 0.6)