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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Hace1tm1Pngr
targeted mutation 1, Josef M Penninger
MGI:3759063
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Hace1tm1Pngr/Hace1tm1Pngr involves: 129P2/OlaHsd * C57BL/6 MGI:3759064
ht2
Hace1tm1Pngr/Hace1+ involves: 129P2/OlaHsd * C57BL/6 MGI:3759065


Genotype
MGI:3759064
hm1
Allelic
Composition
Hace1tm1Pngr/Hace1tm1Pngr
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hace1tm1Pngr mutation (0 available); any Hace1 mutation (55 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
neoplasm
• starting at week 20, mice develop spontaneous tumors as they age including melanomas, hepatocellular carcinomas, spontaneous lung adenocarcinomas, angiosarcomas, mammary carcinomas, lymphomas, sarcomas, and lung and soft tissue tumors
• by 2 years of age, the incidence of spontaneous tumor reaches about 12% compared to 1 to 2% in wild-type and heterozygous mice
• mice treated with a dose of gamma radiation that induces a very low incidence of thymic lymphomas exhibit a 30% incidence with a CD4-CD8-TCRalphabetalow phenotypemice treated with a dose of gamma radiation that induces a very low incidence of thymic lymphomas exhibit a 30% incidence with a CD4-CD8-TCRalphabetalow phenotype
• mice exhibit multifocal, large and rapidly growing lung tumors in response to urethane unlike similarly treated wild-type mice that do not develop lung tumors

respiratory system
• mice exhibit multifocal, large and rapidly growing lung tumors in response to urethane unlike similarly treated wild-type mice that do not develop lung tumors

endocrine/exocrine glands
• mice treated with a dose of gamma radiation that induces a very low incidence of thymic lymphomas exhibit a 30% incidence with a CD4-CD8-TCRalphabetalow phenotypemice treated with a dose of gamma radiation that induces a very low incidence of thymic lymphomas exhibit a 30% incidence with a CD4-CD8-TCRalphabetalow phenotype

hematopoietic system
• mice treated with a dose of gamma radiation that induces a very low incidence of thymic lymphomas exhibit a 30% incidence with a CD4-CD8-TCRalphabetalow phenotypemice treated with a dose of gamma radiation that induces a very low incidence of thymic lymphomas exhibit a 30% incidence with a CD4-CD8-TCRalphabetalow phenotype

immune system
• mice treated with a dose of gamma radiation that induces a very low incidence of thymic lymphomas exhibit a 30% incidence with a CD4-CD8-TCRalphabetalow phenotypemice treated with a dose of gamma radiation that induces a very low incidence of thymic lymphomas exhibit a 30% incidence with a CD4-CD8-TCRalphabetalow phenotype




Genotype
MGI:3759065
ht2
Allelic
Composition
Hace1tm1Pngr/Hace1+
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hace1tm1Pngr mutation (0 available); any Hace1 mutation (55 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
neoplasm
• mice develop a low percentage of lung tumors following treatment with urethane that triggers no lung tumors in wild-type mice

respiratory system
• mice develop a low percentage of lung tumors following treatment with urethane that triggers no lung tumors in wild-type mice





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory