Analysis Tools|
Allele Symbol Allele Name Allele ID |
Grb10Gt(XC302)Byg gene trap XC302, BayGenomics MGI:3759253 |
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| Summary |
5 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• pancreas weight is increased relative to in wild-type mice
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• increase in lean mass is proportional to the increase in body weight
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• mice exhibit increased body weight and size with an increase in both fat and lean mass in males and females relative to wild-type mice
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• insulin sensitivity in muscles was higher than in wild-type mice
• insulin resistance induced by a high fat diet is blunted compared to in wild-type mice
• however, liver insulin sensitivity is normal
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• pancreas weight is increased relative to in wild-type mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• until weaning when Grb10GT(XC302)Byg is inherited maternally
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• when fewer than expected mice are produced no mice are produced when Grb10GT(XC302)Byg is inherited paternally
• however, mice are produced with Grb10GT(XC302)Byg is inherited maternally
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/19/2024 MGI 6.24 |
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