Analysis Tools|
Allele Symbol Allele Name Allele ID |
Tg(Camk2a-cre/ERT2)2Gsc transgene insertion 2, Gunther Schutz MGI:3759305 |
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| Summary |
6 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• when treated with tamoxifen the level of serum corticosterone is increased to 39+/-8 ng/ml when one copies of the transgene is present, 100+/-20 ng/ml when two copies of the transgene are present and 108+/-19 ng/ml when four copies of the transgene are present compared to 13+/-5 ng/ml in wild-type
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• in tamoxifen-treated mice during a dark-light box and elevated plus-maze
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• mice exhibit normal theta burst and high frequency stimulation of long term potentiation
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• tamoxifen-treated mice develop fewer plaques than control mice expressing Tg(APPswe,PSEN1dE9)85Dbo
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• tamoxifen-treated mice exhibit fewer dystrophic neurite clusters and few isolated neurites with residual bodies compared with control mice expressing Tg(APPswe,PSEN1dE9)85Dbo
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• tamoxifen-treated mice develop fewer plaques than control mice expressing Tg(APPswe,PSEN1dE9)85Dbo
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• mice exhibit normal locomotion, sociability, fear conditioning and anxiety related behaviors
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• impaired in tamoxifen-treated mice
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• impaired in tamoxifen-treated mice
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• tamoxifen-treated mice exhibit impaired performance in a water-cross maze and Y-maze
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• reduced size in the cortical and hippocampal pyramidal neurons of tamoxifen-treated mice
• however, general neuron morphology is normal
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• in the cortical and hippocampal pyramidal neurons of tamoxifen-treated mice
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• reduced in tamoxifen-treated mice
• however, excitability is normal
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• at P28, mice treated with tamoxifen during neonatal development exhibit loss of Prox1 expression in most dentate gyrus cells and both mature and immature granule cell properties and intermingled dentate gyrus progenitors in the granular layer unlike control mice
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• at P28, mossy cells are reduced in the hilus compared to in control mice
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• at P28, mice treated with tamoxifen during neonatal development exhibit loss of Prox1 expression in most dentate gyrus cells and both mature and immature granule cell properties unlike control mice
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/12/2024 MGI 6.24 |
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