Phenotypes associated with this allele

• Allele Symbol: Ptges3^tm1Nkt
• Allele Name: targeted mutation 1, Yoshihito Nakatani
• Allele ID: MGI:3759309
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ptges3^tm1Nkt/Ptges3^tm1Nkt	involves: 129P2/OlaHsd * C57BL/6	MGI:3759310

Genotype
MGI:3759310

hm1

• Allelic Composition: Ptges3^tm1Nkt/Ptges3^tm1Nkt
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

perinatal lethality, complete penetrance ( J:125188 )

• while Mendelian ratios of embryos are present at E13 and E16.5 to E18.5, few mice are born and those that are born die at birth due to respiratory distress

growth/size/body

decreased body weight ( J:125188 )

• at E17.5 and E18.5, mice are 80% of the weight of normal mice (0.63+/-0.052 g compared to 0.82+/-0.049 g for wild-type mice)

fetal growth retardation ( J:125188 )

cellular

decreased fibroblast proliferation ( J:125188 )

• cell proliferation of mouse embryonic fibroblasts (MEF) from E13.5 embryos is decreased compared to that of wild-type MEFs

respiratory system

atelectasis ( J:125188 )

• at E18.5, mice have collapsed airspaces in the lungs

respiratory distress ( J:125188 )

• mice that are born suffer from fatal respiratory distress

homeostasis/metabolism

decreased prostaglandin level ( J:125188 )

• PGE2 content in the lungs is decreased compared to in wild-type mice

integument

abnormal dermal layer morphology ( J:125188 )

• at E17.5, hypoplastic alterations are observed

abnormal epidermal layer morphology ( J:125188 )

• at E17.5, hypoplastic alterations are observed

abnormal epidermis stratum corneum morphology ( J:125188 )

• at E17.5, the stratum corneum is insufficient

thin epidermis ( J:125188 )

• at E17.5