Analysis Tools
mortality/aging
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• most mice die before weaning
• however, when raised apart from wild-type sibling mice survive into adolescence
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behavior/neurological
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• while mice respond to administration of SHU9119 and AGRP with increased food intake at 6 hours, this reaction does not persist at 24 hours as it does in wild-type mice
• administration of AGRP results in decreased food consumption at 24 hours and 3 days
• however, similar to in wild-type mice administration of MT-II suppresses food intake
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• unlike in wild-type mice, food intake during the first two days of isolation is reduced compared to the average food intake after 4 weeks of acclimatization
• overall food intake is reduced relative to for wild-type mice when housed individually
• however, injection of leptin was still able to further decrease food intake as in wild-type mice
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• mice are more active than wild-type mice in both the light and dark phase
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growth/size/body
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• when mice are raised separately from wild-type siblings mice survive but weight 30% less than wild-type mice
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weight loss
(
J:125193
)
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• mice lose more weight during the first 6 days of isolation compared to wild-type mice
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• body length of adult mice is greater than 90% of that for wild-type mice
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homeostasis/metabolism
adipose tissue
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• adipocytes of the epididymal fat tissue are reduced in size compared to in wild-type mice
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nervous system
| N |
• mice display no spongiform degeneration or abnormalities in either the fiber densities of AGRP neurons and POMC neurons in the hypothalamus and the dorsal pons or in the abundance of the tyrosine hydroxylase+ neurons in the thalamus and the ventral tegmental area
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