Phenotypes associated with this allele

• Allele Symbol: B3gat1^tm1Tkaw
• Allele Name: targeted mutation 1, Toshisuke Kawasaki
• Allele ID: MGI:3759445
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	B3gat1^tm1Tkaw/B3gat1^tm1Tkaw	B6.129P2-B3gat1^tm1Tkaw	MGI:3759446
hm2	B3gat1^tm1Tkaw/B3gat1^tm1Tkaw	involves: 129P2/OlaHsd	MGI:3849318
cx3	B3gat1^tm1Tkaw/B3gat1^tm1Tkaw B3gat2^tm1Shok/B3gat2^tm1Shok	involves: 129P2/OlaHsd * C57BL/6	MGI:6115795

Genotype
MGI:3759446

hm1

• Allelic Composition: B3gat1^tm1Tkaw/B3gat1^tm1Tkaw
• Genetic Background: B6.129P2-B3gat1^tm1Tkaw

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

reduced long-term potentiation ( J:125254 )

• long term potentiation induced by high frequency stimulation is reduced (131.9+/-8.4% of baseline compared to 161.7+/-7.3% of baseline in wild-type mice)

• however, presynaptic function (basal synaptic transmission paired pulse facilitation and synaptic response to a pair of afferent fiber stimuli) is normal

behavior/neurological

abnormal spatial learning ( J:125254 )

• in a Morris water maze, mice take more time to the hidden platform compared to wild-type mice

• however, motor activity is normal

• in a water-filled T-maze task, mice exhibit increased latency to escape compared to wild-type mice

Genotype
MGI:3849318

hm2

• Allelic Composition: B3gat1^tm1Tkaw/B3gat1^tm1Tkaw
• Genetic Background: involves: 129P2/OlaHsd

behavior/neurological

behavior/neurological phenotype ( J:149762 )

N • mice perform normally on a rotarod and balance beam

Genotype
MGI:6115795

cx3

• Allelic Composition: B3gat1^tm1Tkaw/B3gat1^tm1Tkaw; B3gat2^tm1Shok/B3gat2^tm1Shok
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

mortality/aging

mortality/aging ( J:243894 )

N • viable

reproductive system

reproductive system phenotype ( J:243894 )

N • fertile