All Phenotypes Robo2<tm1Rilm> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Robo2^tm1Rilm
targeted mutation 1, Richard Maas
MGI:3759447

Summary

12 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Robo2^tm1Rilm/Robo2^tm1Rilm	involves: 129 * C57BL/6	MGI:3759460
cn2	Robo2^tm1Rilm/Robo2^tm1Rilm	involves: C57BL/6 * CD-1	MGI:5705332
cn3	Robo1^tm1Matl/Robo1^tm1Matl Robo2^tm1Rilm/Robo2^tm1Rilm Tbx4^tm1(cre)Tmj/Tbx4⁺	involves: 129	MGI:5522804
cn4	Robo1^tm1Matl/Robo1^tm1Matl Robo2^tm1Rilm/Robo2^tm1Rilm Shh^{tm1(EGFP/cre)Cjt}/Shh⁺	involves: 129	MGI:5522668
cn5	Robo2^tm1Rilm/Robo2^tm1Rilm Or8a1b^tm4Mom/? Omp^tm1(cre)Jae/Omp⁺	involves: 129 * 129P2/OlaHsd * 129S1/Sv	MGI:5449874
cn6	Robo2^tm1Rilm/Robo2^tm1Rilm Or51b4^tm1.1Jfcl/? Omp^tm1(cre)Jae/Omp⁺	involves: 129 * 129S1/Sv	MGI:5449875
cn7	Robo2^tm1Rilm/Robo2^tm1Rilm Or5d18^tm1.1Jfcl/? Omp^tm1(cre)Jae/Omp⁺	involves: 129 * 129S1/Sv	MGI:5449872
cn8	Robo2^tm1Rilm/Robo2^tm1Rilm Omp^tm1(cre)Jae/Omp⁺	involves: 129 * 129S1/Sv	MGI:5449871
cn9	Robo1^tm1Matl/Robo1^tm1Matl Robo2^tm1Rilm/Robo2^tm1Rilm Twist2^tm1(cre)Dor/Twist2⁺	involves: 129 * 129X1/SvJ	MGI:5522801
cn10	Robo2^tm1Rilm/Robo2^tm1.1Rilm Tg(EIIa-cre)C5379Lmgd/?	involves: 129 * C57BL/6 * FVB/N	MGI:3759462
cn11	Robo2^tm1Rilm/Robo2^tm1Rilm Tg(Pcp2-cre)2Mpin/?	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1	MGI:5705334
cn12	Pcdhg^tm2Xzw/Pcdhg^tm2Xzw Robo2^tm1Rilm/Robo2^tm1Rilm	involves: 129S7/SvEvBrd * C57BL/6 * CD-1	MGI:5705344

Allelic Composition	Robo2^tm1Rilm/Robo2^tm1Rilm
Genetic Background	involves: 129 * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Robo2^tm1Rilm mutation (1 available); any Robo2 mutation (101 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:125214 )

• mice are viable, fertile and have no kidney abnormalities

Allelic Composition	Robo2^tm1Rilm/Robo2^tm1Rilm
Genetic Background	involves: C57BL/6 * CD-1

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Robo2^tm1Rilm mutation (1 available); any Robo2 mutation (101 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal Purkinje cell dendrite morphology ( J:221288 )

• brain injections of rAAV8 virus expressing cre

• extensive overlaps of Purkinje cell dendritic branches

• dendrites otherwise normal

• crosses are much closer together than the rare crosses seen in controls

• crosses increase as dendrite density increases

• phenotype persists to day 14 and day 60 at least

Allelic Composition	Robo1^tm1Matl/Robo1^tm1Matl Robo2^tm1Rilm/Robo2^tm1Rilm Tbx4^tm1(cre)Tmj/Tbx4⁺
Genetic Background	involves: 129

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Robo1^tm1Matl mutation (2 available); any Robo1 mutation (87 available)
Robo2^tm1Rilm mutation (1 available); any Robo2 mutation (101 available)
Tbx4^tm1(cre)Tmj mutation (0 available); any Tbx4 mutation (23 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:193400 )

• normal lung and diaphragm morphology and normal lung inflation

Allelic Composition	Robo1^tm1Matl/Robo1^tm1Matl Robo2^tm1Rilm/Robo2^tm1Rilm Shh^{tm1(EGFP/cre)Cjt}/Shh⁺
Genetic Background	involves: 129

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Robo1^tm1Matl mutation (2 available); any Robo1 mutation (87 available)
Robo2^tm1Rilm mutation (1 available); any Robo2 mutation (101 available)
Shh^{tm1(EGFP/cre)Cjt} mutation (1 available); any Shh mutation (48 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:193400 )

• normal organ position, diaphragm formation and lung inflation

Allelic Composition	Robo2^tm1Rilm/Robo2^tm1Rilm Or8a1b^tm4Mom/? Omp^tm1(cre)Jae/Omp⁺
Genetic Background	involves: 129 * 129P2/OlaHsd * 129S1/Sv

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Omp^tm1(cre)Jae mutation (0 available); any Omp mutation (27 available)
Or8a1b^tm4Mom mutation (1 available); any Or8a1b mutation (35 available)
Robo2^tm1Rilm mutation (1 available); any Robo2 mutation (101 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal olfactory bulb morphology ( J:173325 )

• an additional lacZ positive glomerulus is detected on the dorsolateral side of the olfactory bulb, only the glomerulus on the medial side is detected in controls

Allelic Composition	Robo2^tm1Rilm/Robo2^tm1Rilm Or51b4^tm1.1Jfcl/? Omp^tm1(cre)Jae/Omp⁺
Genetic Background	involves: 129 * 129S1/Sv

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Omp^tm1(cre)Jae mutation (0 available); any Omp mutation (27 available)
Or51b4^tm1.1Jfcl mutation (0 available); any Or51b4 mutation (10 available)
Robo2^tm1Rilm mutation (1 available); any Robo2 mutation (101 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

nervous system phenotype ( J:173325 )

N	• location of glomeruli from olfactory sensory neurons expressing lacZ is similar to controls

Allelic Composition	Robo2^tm1Rilm/Robo2^tm1Rilm Or5d18^tm1.1Jfcl/? Omp^tm1(cre)Jae/Omp⁺
Genetic Background	involves: 129 * 129S1/Sv

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Omp^tm1(cre)Jae mutation (0 available); any Omp mutation (27 available)
Or5d18^tm1.1Jfcl mutation (0 available); any Or5d18 mutation (14 available)
Robo2^tm1Rilm mutation (1 available); any Robo2 mutation (101 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal olfactory bulb morphology ( J:173325 )

• olfactory sensory neurons expressing GFP are shifted ventrally in the olfactory bulb compared to controls

• in some mice (3 of 12) a third GFP positive glomerulus is detected on the lateral side of the olfactory bulb, a third glomerulus is only seen in 1 control

Allelic Composition	Robo2^tm1Rilm/Robo2^tm1Rilm Omp^tm1(cre)Jae/Omp⁺
Genetic Background	involves: 129 * 129S1/Sv

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Omp^tm1(cre)Jae mutation (0 available); any Omp mutation (27 available)
Robo2^tm1Rilm mutation (1 available); any Robo2 mutation (101 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

abnormal sensory capabilities/reflexes/nociception ( J:173325 )

• display a reduced aversive response and decreased innate avoidance behavior to the predator odorant TMT, a component of fox feces

• however, the responses to 2MB acid, an odorant of spoiled food, are similar to controls

• mice can be conditioned to respond to TMT indicating there is not a defect in detection of this odorant

Allelic Composition	Robo1^tm1Matl/Robo1^tm1Matl Robo2^tm1Rilm/Robo2^tm1Rilm Twist2^tm1(cre)Dor/Twist2⁺
Genetic Background	involves: 129 * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Robo1^tm1Matl mutation (2 available); any Robo1 mutation (87 available)
Robo2^tm1Rilm mutation (1 available); any Robo2 mutation (101 available)
Twist2^tm1(cre)Dor mutation (0 available); any Twist2 mutation (10 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

neonatal lethality ( J:193400 )

digestive/alimentary system

abnormal foregut morphology ( J:193400 )

• closer attachment of foregut to the body wall

small esophagus ( J:193400 )

• shorter

muscle

diaphragmatic hernia ( J:193400 )

• protrusion of the abdominal organs into the chest (stomach or liver)

respiratory system

respiratory failure ( J:193400 )

• inability to inflate lungs at birth

Allelic Composition	Robo2^tm1Rilm/Robo2^tm1.1Rilm Tg(EIIa-cre)C5379Lmgd/?
Genetic Background	involves: 129 * C57BL/6 * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Robo2^tm1.1Rilm mutation (0 available); any Robo2 mutation (101 available)
Robo2^tm1Rilm mutation (1 available); any Robo2 mutation (101 available)
Tg(EIIa-cre)C5379Lmgd mutation (4 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

renal/urinary system

abnormal renal/urinary system morphology ( J:125214 )

• mice exhibit unilateral urinary tract abnormalities, including short ureter, megaureter, and hydronephrosis

kidney cyst ( J:125214 )

• kidney parenchyma is replaced by large cysts

hydronephrosis ( J:125214 )

• ureterovesical junctions associated with obstructions lead to megaureter and hydronephrosis

abnormal ureter morphology ( J:125214 )

• in some males the ureter is connected to the vas deferens resulting in massive hydronephrosis

large ureter ( J:125214 )

• ureterovesical junctions associated with obstructions lead to megaureter and hydronephrosis

short ureter ( J:125214 )

abnormal ureterovesical junction morphology ( J:125214 )

• 7 of 10 mice exhibit bilateral ureterovesical junction defects, where one UVJ is typically located laterally and cephalad in the bladder (commonly associated with reflux in man) whereas the contralateral UVJ is located caudad in the bladder or even ectopically in the urethra

ureterovesical junction obstruction ( J:125214 )

• the caudal UVJ location is associated with obstruction, leading to megaureter and severe hydronephrosis

reproductive system

abnormal vas deferens morphology ( J:125214 )

• in some males the ureter is connected to the vas deferens resulting in massive hydronephrosis

growth/size/body

kidney cyst ( J:125214 )

• kidney parenchyma is replaced by large cysts

Allelic Composition	Robo2^tm1Rilm/Robo2^tm1Rilm Tg(Pcp2-cre)2Mpin/?
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Robo2^tm1Rilm mutation (1 available); any Robo2 mutation (101 available)
Tg(Pcp2-cre)2Mpin mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal Purkinje cell dendrite morphology ( J:221288 )

• extensive overlaps of Purkinje cell dendritic branches

• dendrites otherwise normal

Allelic Composition	Pcdhg^tm2Xzw/Pcdhg^tm2Xzw Robo2^tm1Rilm/Robo2^tm1Rilm
Genetic Background	involves: 129S7/SvEvBrd * C57BL/6 * CD-1

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pcdhg^tm2Xzw mutation (1 available); any Pcdhg mutation (13 available)
Robo2^tm1Rilm mutation (1 available); any Robo2 mutation (101 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal Purkinje cell dendrite morphology ( J:221288 )

• brain injections of rAAV8 virus expressing cre

• higher level of dendritic branch overlap than for either mutant allele alone

behavior/neurological

behavior/neurological phenotype ( J:221288 )

N	• no performance abnormalities in a dowel rod test

abnormal gait ( J:221288 )

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