About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		SufuGt(XB699)Byg
gene trap XB699, BayGenomics
MGI:3759455
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		SufuGt(XB699)Byg/SufuGt(XB699)Byg involves: 129P2/OlaHsd * C57BL/6 MGI:3759456
cx2
 		SufuGt(XB699)Byg/Sufu+
Trp53tm1Tyj/Trp53tm1Tyj 		involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 MGI:3759457


Genotype
MGI:3759456
hm1
Allelic
Composition		 SufuGt(XB699)Byg/SufuGt(XB699)Byg
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
SufuGt(XB699)Byg mutation (0 available); any Sufu mutation (59 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality during organogenesis, complete penetrance ( J:125534 )
• no mice are recovered after E10 due to defects in neural tube closure and heart abnormalities

nervous system

cardiovascular system

embryo




Genotype
MGI:3759457
cx2
Allelic
Composition		 SufuGt(XB699)Byg/Sufu+
Trp53tm1Tyj/Trp53tm1Tyj
Genetic
Background		 involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
SufuGt(XB699)Byg mutation (0 available); any Sufu mutation (59 available)
Trp53tm1Tyj mutation (12 available); any Trp53 mutation (240 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:125534 )
• mice die around 4 months of age compared to Trp53tm1Tyj homozygotes that survive to 5 months

neoplasm
increased rhabdomyosarcoma incidence ( J:125534 )
• unlike SufuGT(XB699)Byg heterozygotes, 5 of 55 mice develop rhabdomyosarcoma
increased lymphoma incidence ( J:125534 )
• unlike SufuGT(XB699)Byg heterozygotes, 8 of 55 mice develop lymphomas or thymomas likely due to Trp53tm1Tyj
increased medulloblastoma incidence ( J:125534 )
• unlike SufuGT(XB699)Byg heterozygotes, 32 of 55 mice develop medulloblastomas that express TUBB3 and GFAP and exhibit increased apoptosis

nervous system
increased medulloblastoma incidence ( J:125534 )
• unlike SufuGT(XB699)Byg heterozygotes, 32 of 55 mice develop medulloblastomas that express TUBB3 and GFAP and exhibit increased apoptosis

muscle
increased rhabdomyosarcoma incidence ( J:125534 )
• unlike SufuGT(XB699)Byg heterozygotes, 5 of 55 mice develop rhabdomyosarcoma

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
medulloblastoma DOID:0050902 OMIM:155255
 J:173443




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory