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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		SufuGt(XB699)Byg
gene trap XB699, BayGenomics
MGI:3759455
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		SufuGt(XB699)Byg/SufuGt(XB699)Byg involves: 129P2/OlaHsd * C57BL/6 MGI:3759456
cx2
 		SufuGt(XB699)Byg/Sufu+
Trp53tm1Tyj/Trp53tm1Tyj 		involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 MGI:3759457


Genotype
MGI:3759456
hm1
Allelic
Composition		 SufuGt(XB699)Byg/SufuGt(XB699)Byg
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
SufuGt(XB699)Byg mutation (0 available); any Sufu mutation (59 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality during organogenesis, complete penetrance ( J:125534 )
• no mice are recovered after E10 due to defects in neural tube closure and heart abnormalities

nervous system

cardiovascular system

embryo




Genotype
MGI:3759457
cx2
Allelic
Composition		 SufuGt(XB699)Byg/Sufu+
Trp53tm1Tyj/Trp53tm1Tyj
Genetic
Background		 involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
SufuGt(XB699)Byg mutation (0 available); any Sufu mutation (59 available)
Trp53tm1Tyj mutation (12 available); any Trp53 mutation (240 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:125534 )
• mice die around 4 months of age compared to Trp53tm1Tyj homozygotes that survive to 5 months

neoplasm
increased rhabdomyosarcoma incidence ( J:125534 )
• unlike SufuGT(XB699)Byg heterozygotes, 5 of 55 mice develop rhabdomyosarcoma
increased lymphoma incidence ( J:125534 )
• unlike SufuGT(XB699)Byg heterozygotes, 8 of 55 mice develop lymphomas or thymomas likely due to Trp53tm1Tyj
increased medulloblastoma incidence ( J:125534 )
• unlike SufuGT(XB699)Byg heterozygotes, 32 of 55 mice develop medulloblastomas that express TUBB3 and GFAP and exhibit increased apoptosis

nervous system
increased medulloblastoma incidence ( J:125534 )
• unlike SufuGT(XB699)Byg heterozygotes, 32 of 55 mice develop medulloblastomas that express TUBB3 and GFAP and exhibit increased apoptosis

muscle
increased rhabdomyosarcoma incidence ( J:125534 )
• unlike SufuGT(XB699)Byg heterozygotes, 5 of 55 mice develop rhabdomyosarcoma

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
medulloblastoma DOID:0050902 OMIM:155255
 J:173443




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory