Phenotypes associated with this allele

• Allele Symbol: Prox1^{tm3(cre/ERT2)Gco}
• Allele Name: targeted mutation 3, Guillermo Oliver
• Allele ID: MGI:3759501
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Prox1^tm3(cre/ERT2)Gco/Prox1^tm3(cre/ERT2)Gco	involves: 129S1/Sv	MGI:3759502
cn2	Gt(ROSA)26Sor^tm1Sor/Gt(ROSA)26Sor^+ Nr2f2^tm2.1Tsa/Nr2f2^tm2.1Tsa Prox1^tm3(cre/ERT2)Gco/Prox1^+	involves: 129S1/Sv * 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6	MGI:4441394

Genotype
MGI:3759502

hm1

• Allelic Composition: Prox1^{tm3(cre/ERT2)Gco}/Prox1^{tm3(cre/ERT2)Gco}
• Genetic Background: involves: 129S1/Sv

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

normal phenotype

no abnormal phenotype detected ( J:125507 )

• mice are viable and show no phenotypic abnormalities

Genotype
MGI:4441394

cn2

• Allelic Composition: Gt(ROSA)26Sor^tm1Sor/Gt(ROSA)26Sor⁺; Nr2f2^tm2.1Tsa/Nr2f2^tm2.1Tsa; Prox1^{tm3(cre/ERT2)Gco}/Prox1⁺
• Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6

immune system

abnormal lymphatic vessel morphology ( J:158959 )

• embryos exposed to tamoxifen at E10.5-12.5 show some blood-filled dermal lymphatic vessels

• embryos exposed to tamoxifen show reduced number of superficial vessels (X-gal stained); severity of reduction increases with early tamoxifen treatment

• tamoxifen treatment at E10.5 or E11.5 results in severely reduced lymphatic endothelial cell numbers and lack of lymphatic vessels

• embryos exposed to tamoxifen at E10.5 or 11.5 display drastically mispatterned lymph sacs that are reduced in size compared to controls

• when tamoxifen exposure occurs at E13.5, few embryos show any lymphatic defects, while exposure later in development or postnatally causes no obvious defects despite reduction in Nr2f2 expression in LECs

homeostasis/metabolism

edema ( J:158959 )

• embryos exposed to tamoxifen at E10.5-12.5 (analyzed at E15.5) display edema