Phenotypes associated with this allele

• Allele Symbol: Pfkm^{GT(OST56064)Lex}
• Allele Name: gene trap OST56064, Lexicon Genetics
• Allele ID: MGI:3759504
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Pfkm^GT(OST56064)Lex/Pfkm^GT(OST56064)Lex	involves: 129S5/SvEvBrd * C57BL/6	MGI:3759539

Genotype
MGI:3759539

hm1

• Allelic Composition: Pfkm^{GT(OST56064)Lex}/Pfkm^{GT(OST56064)Lex}
• Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

abnormal glucose homeostasis ( J:125530 )

• islet insulin levels are increase 20% compared to in wild-type islets

decreased insulin secretion ( J:125530 )

• islet cells secrete 50% less insulin in responses to 11 or 16.7 mM glucose

• the amplitude of insulin pulses are reduced

• however, the period of insulin pulses are normal

increased circulating glucose level ( J:125530 )

• fasting blood glucose levels are elevated (7.6+/-0.3 mM compared to 4.6+/-0.6 mM in wild-type mice)

• basal blood glucose levels are elevated in nonfasting animals (11.2+/-0.3 mM compared to 8.2+/-0.2 mM in wild-type mice)

decreased circulating insulin level ( J:125530 )

• the percentage increase in glucose-stimulated insulin levels is reduced (42+/-15% compared to 140+/-32% in wild-type mice)

impaired glucose tolerance ( J:125530 )

• 0.44+/-0.07 ng/ml compared to 0.34+/-0.08 ng/ml in wild-type mice

endocrine/exocrine glands

decreased insulin secretion ( J:125530 )

• islet cells secrete 50% less insulin in responses to 11 or 16.7 mM glucose

• the amplitude of insulin pulses are reduced

• however, the period of insulin pulses are normal