About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(Spry2)2Tpo
transgene insertion 2, Timothy P O'Brien
MGI:3759546
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cx1
Ednrbs-36Pub/Ednrbs-36Pub
Tg(Spry2)2Tpo/0
B6.Cg-Ednrbs-36Pub Tg(Spry2)2Tpo MGI:3759582


Genotype
MGI:3759582
cx1
Allelic
Composition
Ednrbs-36Pub/Ednrbs-36Pub
Tg(Spry2)2Tpo/0
Genetic
Background
B6.Cg-Ednrbs-36Pub Tg(Spry2)2Tpo
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ednrbs-36Pub mutation (0 available); any Ednrb mutation (104 available)
Tg(Spry2)2Tpo mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
craniofacial
N
• transgenic mice show complete rescue of cleft lip phenotype
• at E18.5, bones of hard palate are reduced in size and show altered morphology
• at E18.5, palatal processes of maxilla are reduced in size and show altered morphology
• incidence of cleft secondary palate is reduced to 42% in non-transgenic homozygotes

skeleton
• at E18.5, bones of hard palate are reduced in size and show altered morphology
• at E18.5, palatal processes of maxilla are reduced in size and show altered morphology

digestive/alimentary system
• at E18.5, bones of hard palate are reduced in size and show altered morphology
• at E18.5, palatal processes of maxilla are reduced in size and show altered morphology
• incidence of cleft secondary palate is reduced to 42% in non-transgenic homozygotes

growth/size/body
• at E18.5, bones of hard palate are reduced in size and show altered morphology
• at E18.5, palatal processes of maxilla are reduced in size and show altered morphology
• incidence of cleft secondary palate is reduced to 42% in non-transgenic homozygotes





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
11/19/2024
MGI 6.24
The Jackson Laboratory