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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(Spry2)2Tpo
transgene insertion 2, Timothy P O'Brien
MGI:3759546
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cx1
Ednrbs-36Pub/Ednrbs-36Pub
Tg(Spry2)2Tpo/0
B6.Cg-Ednrbs-36Pub Tg(Spry2)2Tpo MGI:3759582


Genotype
MGI:3759582
cx1
Allelic
Composition
Ednrbs-36Pub/Ednrbs-36Pub
Tg(Spry2)2Tpo/0
Genetic
Background
B6.Cg-Ednrbs-36Pub Tg(Spry2)2Tpo
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ednrbs-36Pub mutation (0 available); any Ednrb mutation (104 available)
Tg(Spry2)2Tpo mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
craniofacial
N
• transgenic mice show complete rescue of cleft lip phenotype
• at E18.5, bones of hard palate are reduced in size and show altered morphology
• at E18.5, palatal processes of maxilla are reduced in size and show altered morphology
• incidence of cleft secondary palate is reduced to 42% in non-transgenic homozygotes

skeleton
• at E18.5, bones of hard palate are reduced in size and show altered morphology
• at E18.5, palatal processes of maxilla are reduced in size and show altered morphology

digestive/alimentary system
• at E18.5, bones of hard palate are reduced in size and show altered morphology
• at E18.5, palatal processes of maxilla are reduced in size and show altered morphology
• incidence of cleft secondary palate is reduced to 42% in non-transgenic homozygotes

growth/size/body
• at E18.5, bones of hard palate are reduced in size and show altered morphology
• at E18.5, palatal processes of maxilla are reduced in size and show altered morphology
• incidence of cleft secondary palate is reduced to 42% in non-transgenic homozygotes





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last database update
12/10/2024
MGI 6.24
The Jackson Laboratory