All Phenotypes Cdk2<tm2Sgo> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Cdk2^tm2Sgo
targeted mutation 2, Sagrario Ortega
MGI:3759555

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Cdk2^tm2Sgo/Cdk2^tm2Sgo Kras^tm1Bbd/Kras^tm2Bbd Polr2a^{tm1(cre/ERT2)Bbd}/Polr2a^{tm1(cre/ERT2)Bbd}	involves: 129S1/Sv * 129X1/SvJ	MGI:4844189
cn2	Cdk2^tm2Sgo/Cdk2^tm2Sgo Cdk4^tm2.1Bbd/Cdk4^tm2.1Bbd Polr2a^{tm1(cre/ERT2)Bbd}/?	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL	MGI:3759577

Allelic Composition	Cdk2^tm2Sgo/Cdk2^tm2Sgo Kras^tm1Bbd/Kras^tm2Bbd Polr2a^{tm1(cre/ERT2)Bbd}/Polr2a^{tm1(cre/ERT2)Bbd}
Genetic Background	involves: 129S1/Sv * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdk2^tm2Sgo mutation (1 available); any Cdk2 mutation (18 available)
Kras^tm1Bbd mutation (2 available); any Kras mutation (84 available)
Kras^tm2Bbd mutation (0 available); any Kras mutation (84 available)
Polr2a^{tm1(cre/ERT2)Bbd} mutation (3 available); any Polr2a mutation (92 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:161780 )

• tamoxifen-treated mice exhibit an increase in lifespan compared with similarly treated Kras^tm1Bbd/Kras⁺ Polr2a^{tm1(cre/ERT2)Bbd}/Polr2a^{tm1(cre/ERT2)Bbd} littermates

neoplasm

decreased tumor incidence ( J:161780 )

• tamoxifen-treated mice exhibit reduced tumor burden and tumor grade compared with similarly treated Kras^tm1Bbd/Kras⁺ Polr2a^{tm1(cre/ERT2)Bbd}/Polr2a^{tm1(cre/ERT2)Bbd} mice

Allelic Composition	Cdk2^tm2Sgo/Cdk2^tm2Sgo Cdk4^tm2.1Bbd/Cdk4^tm2.1Bbd Polr2a^{tm1(cre/ERT2)Bbd}/?
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdk2^tm2Sgo mutation (1 available); any Cdk2 mutation (18 available)
Cdk4^tm2.1Bbd mutation (1 available); any Cdk4 mutation (58 available)
Polr2a^{tm1(cre/ERT2)Bbd} mutation (3 available); any Polr2a mutation (92 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

decreased body size ( J:125217 )

• when 5 month old mice were treated with tamoxifen they exhibit reduced body size associated with the loss of the Cdk4 function

immune system

increased susceptibility to autoimmune diabetes ( J:125217 )

• when 5 month old mice were treated with tamoxifen they exhibit diabetes associated with the loss of the Cdk4 function

hematopoietic system

hematopoietic system phenotype ( J:125217 )

N	• adult hematopoiesis is normal following tamoxifen treatment at 5 months of age

liver/biliary system

liver/biliary system phenotype ( J:125217 )

N	• liver regeneration is normal following tamoxifen treatment at 5 months of age

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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