All Phenotypes Clca1<tm1.1Lex> MGI Mouse

lung inflammation ( J:125158 )

• following sensitization with ovalbumin and challenge with aerosolized ovalbumin or LPS-challenge, mice exhibit a higher total bronchoalveolar lavage cell inflammation compared to similarly treated wild-type mice

abnormal lung epithelium morphology ( J:125158 )

• following ovalbumin-challenge, mice exhibit a decreased thickening in lung epithelium compared to similarly treated wild-type mice

• following LPS-challenge, mice do not respond by thickening their lung epithelium as do similarly treated wild-type mice

abnormal respiratory mucosa goblet cell morphology ( J:125158 )

• following ovalbumin-challenge, goblet cell (PAS+) hyperplasia is reduced compared to in similarly treated wild-type mice

decreased airway resistance ( J:125158 )

• following ovalbumin-challenge and methacholine provocation, mice exhibit a decrease in airway resistance compared to similarly treated wild-type mice

increased neutrophil cell number ( J:125158 )

• following sensitization with olavbumin and challenge with aerosolized ovalbumin or LPS-challenge, mice exhibit a higher number of neutrophils compared to in wild-type mice

abnormal chemokine level ( J:125158 )

• following LPS-stimulation, CXCL1 levels are increased compared to in similarly treated wild-type mice

• however, LPS-stimulation induces normal amounts of IL17a and CXCL2

increased inflammatory response ( J:125158 )

• following sensitization with ovalbumin and challenge with aerosolized ovalbumin or LPS-challenge, mice exhibit a decrease in perivascular inflammation compared to wild-type mice