All Phenotypes Nup98<tm1Jvd> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Nup98^tm1Jvd
targeted mutation 1, Jan M A van Deursen
MGI:3759762

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Nup98^tm1Jvd/Nup98^tm1Jvd	Not Specified	MGI:3759764
cx2	Nup88^em1Jvd/Nup88⁺ Nup98^tm1Jvd/Nup98⁺ Rae1^tm1Jvd/Rae1⁺	involves: C57BL/6	MGI:6377639
cx3	Nup98^tm1Jvd/Nup98⁺ Rae1^tm1Jvd/Rae1⁺	Not Specified	MGI:6377636

Allelic Composition	Nup98^tm1Jvd/Nup98^tm1Jvd
Genetic Background	Not Specified

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nup98^tm1Jvd mutation (0 available); any Nup98 mutation (146 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

perinatal lethality, complete penetrance ( J:125571 )

• no mice are recovered at birth

embryo

abnormal embryo development ( J:125571 )

• embryonic development at E8.5 is grossly retarded and embryos are highly disorganized with defects in morphogenesis, proliferation and pattern formation

• E8.5 embryos grown in culture take 80 to 100 days to develop into epithelial-like cells compared to wild-type cells that only take 10 to 20 days to do so

abnormal gastrulation ( J:125571 )

decreased embryo size ( J:125571 )

• at E8.5 embryos are the size of normal E6.5 to E7.5 embryos

growth/size/body

decreased embryo size ( J:125571 )

• at E8.5 embryos are the size of normal E6.5 to E7.5 embryos

Allelic Composition	Nup88^em1Jvd/Nup88⁺ Nup98^tm1Jvd/Nup98⁺ Rae1^tm1Jvd/Rae1⁺
Genetic Background	involves: C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nup88^em1Jvd mutation (0 available); any Nup88 mutation (44 available)
Nup98^tm1Jvd mutation (0 available); any Nup98 mutation (146 available)
Rae1^tm1Jvd mutation (0 available); any Rae1 mutation (23 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

abnormal mitosis ( J:231166 )

• chromosome segregation errors are reduced to 18% from 37% in double Rae1^tm1Jvd Nup98^tm1Jvd heterozygotes and the mitotic checkpoint is fully restored

Allelic Composition	Nup98^tm1Jvd/Nup98⁺ Rae1^tm1Jvd/Rae1⁺
Genetic Background	Not Specified

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nup98^tm1Jvd mutation (0 available); any Nup98 mutation (146 available)
Rae1^tm1Jvd mutation (0 available); any Rae1 mutation (23 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

abnormal cell cycle checkpoint function ( J:231166 )

• MEFs exhibit mitotic checkpoint defects

abnormal mitosis ( J:231166 )

• MEFs have increased rates of chromatin bridges and lagging chromosomes indicating chromosome segregation errors

• incomplete centrosome separation is increased in MEFs

• MEFs treated with the PLK1 inhibitor BI2536 show restoration of normal centrosome separation

abnormal mitotic spindle morphology ( J:231166 )

• MEFs exhibit more frequent spindle geometry defects showing mitotic spindle asymmetry

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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