All Phenotypes Tg(CAG-EGFP/Map1lc3b)53Nmz MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Tg(CAG-EGFP/Map1lc3b)53Nmz
transgene insertion 53, Noboru Mizushima
MGI:3759813

Summary

25 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Atg7^tm1Tchi/Atg7^tm1Tchi Lyz2^tm1(cre)Ifo/Lyz2⁺ Tg(CAG-EGFP/Map1lc3b)53Nmz/0	involves: 129P2/OlaHsd * C57BL/6 * C57BL/6NCrlj * CBA/JNCrlj * DBA/2	MGI:6287974
cn2	Atg5^tm1Myok/Atg5^tm1Myok Tg(CAG-EGFP/Map1lc3b)53Nmz/0 Tg(Cryaa-cre)10Mlr/0	involves: 129S/SvEv * C57BL/6 * DBA/2 * FVB/N	MGI:5529811
cn3	Pik3c3^{tm1c(EUCOMM)Wtsi}/Pik3c3^{tm1c(EUCOMM)Wtsi} Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺ Tg(CAG-EGFP/Map1lc3b)53Nmz/0	involves: C57BL/6 * C57BL/6N * C57BL/6NCrj * DBA	MGI:5427446
cn4	Bag3^{tm1c(EUCOMM)Hmgu}/Bag3^{tm1c(EUCOMM)Hmgu} Tg(CAG-EGFP/Map1lc3b)53Nmz/0 Tg(Myhca-cre)1Abel/0	involves: C57BL/6 * C57BL/6N * C57BL/6NCrlj * DBA/2 * FVB/N	MGI:6107905
cn5	Pik3c3^{tm1c(EUCOMM)Wtsi}/Pik3c3^{tm1c(EUCOMM)Wtsi} Tg(CAG-EGFP/Map1lc3b)53Nmz/0	involves: C57BL/6N * C57BL/6NCrj	MGI:5427442
cn6	Pik3c3^{tm1c(EUCOMM)Wtsi}/Pik3c3^{tm1c(EUCOMM)Wtsi} Tg(CAG-EGFP/Map1lc3b)53Nmz/0 Tg(Ckmm-cre)5Khn/0	involves: C57BL/6N * C57BL/6NCrj * FVB/N	MGI:5427445
cn7	Fis1^tm1.1Itl/Fis1^tm1.1Itl Tg(CAG-EGFP/Map1lc3b)53Nmz/0 Tg(Ckmm-cre)5Khn/0	involves: C57BL/6NCrlj * C57BL/6NTac * DBA/2 * FVB	MGI:6444642
cx8	Becn1^tm2.1Blev/Becn1^tm2.1Blev Tg(CAG-EGFP/Map1lc3b)53Nmz/0	involves: 129 * C57BL/6 * C57BL/6J * C57BL/6NCrlj * DBA/2	MGI:6257019
cx9	Atg16l1^{Gt(BC0122)Wtsi}/Atg16l1^{Gt(BC0122)Wtsi} Tg(CAG-EGFP/Map1lc3b)53Nmz/0	involves: 129P2/OlaHsd * C57BL/6NCrj	MGI:5313721
cx10	Atg5^tm1Nmz/Atg5^tm1Nmz Tg(CAG-EGFP/Map1lc3b)53Nmz/?	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:3814239
cx11	Tigar^tm1.2Smat/Tigar^tm1.2Smat Tg(CAG-EGFP/Map1lc3b)53Nmz/0	involves: 129S1/Sv * 129X1/SvJ * C57BL/6JJcl * C57BL/6NCrj	MGI:5319196
cx12	Trp53^tm1Tyj/Trp53^tm1Tyj Tg(CAG-EGFP/Map1lc3b)53Nmz/0	involves: 129S2/SvPas * C57BL/6 * C57BL/6NCrj	MGI:5319199
cx13	Tsc2^tm1Djk/Tsc2⁺ Tg(CAG-EGFP/Map1lc3b)53Nmz/0	involves: 129S4/SvJae * C57BL/6 * C57BL/6J * C57BL/6NCrlj * DBA/2	MGI:5824122
cx14	Map1s^tm1.1Lliu/Map1s^tm1.1Lliu Tg(CAG-EGFP/Map1lc3b)53Nmz/0	involves: 129S4/SvJaeSor * C57BL/6 * C57BL/6NCrj	MGI:4948445
cx15	Atg4d^{Gt(OST254045)Lex}/Atg4d^{Gt(OST254045)Lex} Tg(CAG-EGFP/Map1lc3b)53Nmz/0	involves: 129S5/SvEvBrd * C57BL/6J * C57BL/6NCrlj * DBA/2J	MGI:6827352
cx16	Bcl2^tm1.1Sjk/Bcl2^tm1.1Sjk Tg(CAG-EGFP/Map1lc3b)53Nmz/0	involves: 129X1/SvJ * C57BL/6 * C57BL/6NCrj * SJL	MGI:5313437
cx17	Dapk1^tm1Akc/Dapk1^tm1Akc Tg(CAG-EGFP/Map1lc3b)53Nmz/0	involves: 129X1/SvJ * C57BL/6J * C57BL/6NCrj	MGI:4440536
cx18	Becn1^tm1Blev/Becn1⁺ Tg(CAG-EGFP/Map1lc3b)53Nmz/0	involves: 129X1/SvJ * C57BL/6J * C57BL/6NCrj	MGI:3837449
cx19	Becn1^tm1Blev/Becn1⁺ Tg(CAG-EGFP/Map1lc3b)53Nmz/0	involves: 129X1/SvJ * C57BL/6NCrj	MGI:5313436
cx20	Rubcn^em1Dgre/Rubcn^em1Dgre Tg(CAG-EGFP/Map1lc3b)53Nmz/0	involves: C57BL/6 * C57BL/6J * C57BL/6N * C57BL/6NCrlj * DBA/2	MGI:6196878
cx21	AA467197^em1Nyam/AA467197^em1Nyam Tg(CAG-EGFP/Map1lc3b)53Nmz/0	involves: C57BL/6J * C57BL/6NCrlj * DBA/2	MGI:7624460
cx22	Sox2^tm1.2Lan/Sox2^tm1.2Lan Tg(CAG-EGFP/Map1lc3b)53Nmz/0	involves: C57BL/6 * C57BL/6NCrlj * DBA/2 * FVB/N	MGI:5572910
cx23	Rubcn^em1Dgre/Rubcn^em1Dgre Tg(CAG-EGFP/Map1lc3b)53Nmz/0	involves: C57BL/6 * C57BL/6N * DBA/2	MGI:6287979
cx24	Glipr2^em1Blev/Glipr2^em1Blev Tg(CAG-EGFP/Map1lc3b)53Nmz/0	involves: C57BL/6J * DBA/2	MGI:6828762
cx25	Tg(CAG-EGFP/Map1lc3b)53Nmz/0 Tg(Myh6-Gsk3b*)19Jusa/0	involves: C57BL/6NCrj * FVB/N	MGI:5471802

Allelic Composition	Atg7^tm1Tchi/Atg7^tm1Tchi Lyz2^tm1(cre)Ifo/Lyz2⁺ Tg(CAG-EGFP/Map1lc3b)53Nmz/0
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * C57BL/6NCrlj * CBA/JNCrlj * DBA/2

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atg7^tm1Tchi mutation (3 available); any Atg7 mutation (51 available)
Lyz2^tm1(cre)Ifo mutation (14 available); any Lyz2 mutation (40 available)
Tg(CAG-EGFP/Map1lc3b)53Nmz mutation (5 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

abnormal macrophage physiology ( J:235399 )

• mice injected with UV-irradiated dying thymocytes into the spleen, liver, or kidney exhibit defective clearance of engulfed, dying cells and no induction of LC3-II, indicating failure of LC3-associated phagocytosis-dependent mechanism to degrade engulfed corpses

homeostasis/metabolism

abnormal circulating chemokine level ( J:235399 )

• serum CCL4 levels are increased in mice injected with UV-irradiated dying thymocytes

increased circulating interleukin-1 beta level ( J:235399 )

• serum IL-1beta levels are increased in mice injected with UV-irradiated dying thymocytes

decreased circulating interleukin-10 level ( J:235399 )

• serum IL-10 levels are not increased in mutant mice injected with UV-irradiated dying thymocytes like in wild-type mice

increased circulating interleukin-6 level ( J:235399 )

• serum IL-6 levels are increased in mice injected with UV-irradiated dying thymocytes

immune system

abnormal macrophage physiology ( J:235399 )

abnormal circulating chemokine level ( J:235399 )

• serum CCL4 levels are increased in mice injected with UV-irradiated dying thymocytes

increased circulating interleukin-1 beta level ( J:235399 )

• serum IL-1beta levels are increased in mice injected with UV-irradiated dying thymocytes

decreased circulating interleukin-10 level ( J:235399 )

• serum IL-10 levels are not increased in mutant mice injected with UV-irradiated dying thymocytes like in wild-type mice

increased circulating interleukin-6 level ( J:235399 )

• serum IL-6 levels are increased in mice injected with UV-irradiated dying thymocytes

Allelic Composition	Atg5^tm1Myok/Atg5^tm1Myok Tg(CAG-EGFP/Map1lc3b)53Nmz/0 Tg(Cryaa-cre)10Mlr/0
Genetic Background	involves: 129S/SvEv * C57BL/6 * DBA/2 * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atg5^tm1Myok mutation (3 available); any Atg5 mutation (29 available)
Tg(CAG-EGFP/Map1lc3b)53Nmz mutation (5 available)
Tg(Cryaa-cre)10Mlr mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Cataract development in Atg5^tm1Myok/Atg5^tm1Myok Tg(CAG-EGFP/Map1lc3b)53Nmz/0 Tg(Cryaa-cre)10Mlr/0 mice

homeostasis/metabolism

impaired autophagy ( J:198392 )

• absent in lens fiber cells

vision/eye

abnormal lens fiber morphology ( J:198392 )

• absent autophagy in lens fiber cells

• disorganized in the cortical region of aged mice

• however, organelle degradation is normal

cataract ( J:198392 )

• by 6 to 9 months that develops progressively with age

• severe, bilateral at 21 months

• with accumulation of insoluble oxidized proteins and crystallins

cellular

impaired autophagy ( J:198392 )

• absent in lens fiber cells

Allelic Composition	Pik3c3^{tm1c(EUCOMM)Wtsi}/Pik3c3^{tm1c(EUCOMM)Wtsi} Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺ Tg(CAG-EGFP/Map1lc3b)53Nmz/0
Genetic Background	involves: C57BL/6 * C57BL/6N * C57BL/6NCrj * DBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pik3c3^{tm1c(EUCOMM)Wtsi} mutation (1 available); any Pik3c3 mutation (48 available)
Speer6-ps1^{Tg(Alb-cre)21Mgn} mutation (6 available); any Speer6-ps1 mutation (4 available)
Tg(CAG-EGFP/Map1lc3b)53Nmz mutation (5 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

liver/biliary system

abnormal liver physiology ( J:182628 )

• livers from fed and starved exhibit blocked autophagy flux compared with control livers

cellular

abnormal autophagy ( J:182628 )

• livers from fed and starved exhibit blocked autophagy flux compared with control livers

homeostasis/metabolism

abnormal autophagy ( J:182628 )

• livers from fed and starved exhibit blocked autophagy flux compared with control livers

Allelic Composition	Bag3^{tm1c(EUCOMM)Hmgu}/Bag3^{tm1c(EUCOMM)Hmgu} Tg(CAG-EGFP/Map1lc3b)53Nmz/0 Tg(Myhca-cre)1Abel/0
Genetic Background	involves: C57BL/6 * C57BL/6N * C57BL/6NCrlj * DBA/2 * FVB/N
Cell Lines	HEPD0556_7_B06

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bag3^{tm1c(EUCOMM)Hmgu} mutation (2 available); any Bag3 mutation (31 available)
Tg(CAG-EGFP/Map1lc3b)53Nmz mutation (5 available)
Tg(Myhca-cre)1Abel mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

impaired autophagy ( J:246352 )

• after 18 hours of starvation, mice exhibit a reduction in LC3-GFP accumulation in the myocardium, indicating suppressed autophagic flux in hearts

homeostasis/metabolism

impaired autophagy ( J:246352 )

• after 18 hours of starvation, mice exhibit a reduction in LC3-GFP accumulation in the myocardium, indicating suppressed autophagic flux in hearts

Allelic Composition	Pik3c3^{tm1c(EUCOMM)Wtsi}/Pik3c3^{tm1c(EUCOMM)Wtsi} Tg(CAG-EGFP/Map1lc3b)53Nmz/0
Genetic Background	involves: C57BL/6N * C57BL/6NCrj

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pik3c3^{tm1c(EUCOMM)Wtsi} mutation (1 available); any Pik3c3 mutation (48 available)
Tg(CAG-EGFP/Map1lc3b)53Nmz mutation (5 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

abnormal autophagy ( J:182628 )

• fed and nutrient-starved conditions mouse embryonic fibroblasts transduced with a cre-expressing adenovirus exhibit blocked autophagy flux unlike control cells

homeostasis/metabolism

abnormal autophagy ( J:182628 )

• fed and nutrient-starved conditions mouse embryonic fibroblasts transduced with a cre-expressing adenovirus exhibit blocked autophagy flux unlike control cells

Allelic Composition	Pik3c3^{tm1c(EUCOMM)Wtsi}/Pik3c3^{tm1c(EUCOMM)Wtsi} Tg(CAG-EGFP/Map1lc3b)53Nmz/0 Tg(Ckmm-cre)5Khn/0
Genetic Background	involves: C57BL/6N * C57BL/6NCrj * FVB/N

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

abnormal myocardial fiber physiology ( J:182628 )

• hearts from fed and starved exhibit blocked autophagy flux compared with control hearts

cellular

abnormal autophagy ( J:182628 )

• hearts from fed and starved exhibit blocked autophagy flux compared with control hearts

homeostasis/metabolism

abnormal autophagy ( J:182628 )

• hearts from fed and starved exhibit blocked autophagy flux compared with control hearts

Allelic Composition	Fis1^tm1.1Itl/Fis1^tm1.1Itl Tg(CAG-EGFP/Map1lc3b)53Nmz/0 Tg(Ckmm-cre)5Khn/0
Genetic Background	involves: C57BL/6NCrlj * C57BL/6NTac * DBA/2 * FVB

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fis1^tm1.1Itl mutation (0 available); any Fis1 mutation (47 available)
Tg(CAG-EGFP/Map1lc3b)53Nmz mutation (5 available)
Tg(Ckmm-cre)5Khn mutation (4 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

abnormal autophagy ( J:290485 )

• increased GFP-LC3 puncta containing mitochondria in the soleus of sedentary mice

homeostasis/metabolism

abnormal autophagy ( J:290485 )

• increased GFP-LC3 puncta containing mitochondria in the soleus of sedentary mice

Allelic Composition	Becn1^tm2.1Blev/Becn1^tm2.1Blev Tg(CAG-EGFP/Map1lc3b)53Nmz/0
Genetic Background	involves: 129 * C57BL/6 * C57BL/6J * C57BL/6NCrlj * DBA/2

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Becn1^tm2.1Blev mutation (1 available); any Becn1 mutation (36 available)
Tg(CAG-EGFP/Map1lc3b)53Nmz mutation (5 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

enhanced autophagy ( J:244104 )

• under fed and resting conditions, mice exhibit a higher number of autophagosomes in skeletal muscle and brain, indicating high basal autophagy

homeostasis/metabolism

enhanced autophagy ( J:244104 )

• under fed and resting conditions, mice exhibit a higher number of autophagosomes in skeletal muscle and brain, indicating high basal autophagy

Allelic Composition	Atg16l1^{Gt(BC0122)Wtsi}/Atg16l1^{Gt(BC0122)Wtsi} Tg(CAG-EGFP/Map1lc3b)53Nmz/0
Genetic Background	involves: 129P2/OlaHsd * C57BL/6NCrj

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atg16l1^{Gt(BC0122)Wtsi} mutation (1 available); any Atg16l1 mutation (44 available)
Tg(CAG-EGFP/Map1lc3b)53Nmz mutation (5 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

impaired autophagy ( J:181308 )

• reduced exercised-induced autophagy in skeletal muscles compared to in wild-type muscles

homeostasis/metabolism

impaired autophagy ( J:181308 )

• reduced exercised-induced autophagy in skeletal muscles compared to in wild-type muscles

Allelic Composition	Atg5^tm1Nmz/Atg5^tm1Nmz Tg(CAG-EGFP/Map1lc3b)53Nmz/?
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atg5^tm1Nmz mutation (1 available); any Atg5 mutation (29 available)
Tg(CAG-EGFP/Map1lc3b)53Nmz mutation (5 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

abnormal autophagosome formation ( J:140583 )

• E15.5 thymus cells fail to form autophagosomes as occurs in the wild-type fetal thymus

mortality/aging

neonatal lethality, complete penetrance ( J:140583 )

• neonatal lethality occurs, caused in part by perinatal metabolic process

cellular

abnormal autophagosome formation ( J:140583 )

• E15.5 thymus cells fail to form autophagosomes as occurs in the wild-type fetal thymus

hematopoietic system

abnormal thymus morphology ( J:140583 )

• E15.5 thymus cells fail to form autophagosomes as occurs in the wild-type fetal thymus

abnormal thymus physiology ( J:140583 )

• embryonic thymi transplanted under the renal capsule of athymic hosts develop and release CD4 ⁺ T cells that mount an autoimmune attack

• this autoimmune attack leads to patches of flaky skin, a massively enlarged colon, atrophy of the uterus, complete absence of fat pads and in many cases enlarged lymph nodes

immune system

abnormal thymus morphology ( J:140583 )

• E15.5 thymus cells fail to form autophagosomes as occurs in the wild-type fetal thymus

abnormal thymus physiology ( J:140583 )

• embryonic thymi transplanted under the renal capsule of athymic hosts develop and release CD4 ⁺ T cells that mount an autoimmune attack

• this autoimmune attack leads to patches of flaky skin, a massively enlarged colon, atrophy of the uterus, complete absence of fat pads and in many cases enlarged lymph nodes

endocrine/exocrine glands

abnormal thymus morphology ( J:140583 )

• E15.5 thymus cells fail to form autophagosomes as occurs in the wild-type fetal thymus

abnormal thymus physiology ( J:140583 )

• embryonic thymi transplanted under the renal capsule of athymic hosts develop and release CD4 ⁺ T cells that mount an autoimmune attack

• this autoimmune attack leads to patches of flaky skin, a massively enlarged colon, atrophy of the uterus, complete absence of fat pads and in many cases enlarged lymph nodes

Allelic Composition	Tigar^tm1.2Smat/Tigar^tm1.2Smat Tg(CAG-EGFP/Map1lc3b)53Nmz/0
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6JJcl * C57BL/6NCrj

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(CAG-EGFP/Map1lc3b)53Nmz mutation (5 available)
Tigar^tm1.2Smat mutation (0 available); any Tigar mutation (58 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

abnormal heart morphology ( J:183674 )

• following permanent coronary artery ligation, mice exhibit decreased apoptotic myocyte death and improved cardiac remodeling (smaller fibrotic lesions, decreased cardiac hyperplasia, improved left ventricle size and contractility and decreased accumulation of damaged mitochondria) compared with wild-type mice

increased cardiac muscle contractility ( J:183674 )

• following myocardial infarction

abnormal response to cardiac infarction ( J:183674 )

• following myocardial infarction, cardiac muscles exhibit increased autophagy, levels of reactive oxygen species production mitophagy and decreased mitochondria DNA damage compared to in wild-type mice

cellular

abnormal mitochondrial chromosome morphology ( J:183674 )

• following myocardial infarction, cardiac muscles exhibit decreased mitochondria DNA damage compared to in wild-type mice

• however, treatment with chloroquine elevates mitochondria DNA damage to wild-type levels

abnormal autophagy ( J:183674 )

• following myocardial infarction, autophagy in cardiac muscles is increased compared to in wild-type mice

decreased cardiomyocyte apoptosis ( J:183674 )

• following myocardial infarction

abnormal mitochondrial physiology ( J:183674 )

• following myocardial infarction, cardiac muscles exhibit increased mitophagy compared to in wild-type mice

• however, treatment with chloroquine elevates mitochondrial to wild-type levels

oxidative stress ( J:183674 )

• following myocardial infarction, cardiac muscles exhibit increased levels of reactive oxygen species production compared to in wild-type mice

homeostasis/metabolism

abnormal response to cardiac infarction ( J:183674 )

abnormal autophagy ( J:183674 )

• following myocardial infarction, autophagy in cardiac muscles is increased compared to in wild-type mice

muscle

increased cardiac muscle contractility ( J:183674 )

• following myocardial infarction

decreased cardiomyocyte apoptosis ( J:183674 )

• following myocardial infarction

Allelic Composition	Trp53^tm1Tyj/Trp53^tm1Tyj Tg(CAG-EGFP/Map1lc3b)53Nmz/0
Genetic Background	involves: 129S2/SvPas * C57BL/6 * C57BL/6NCrj

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(CAG-EGFP/Map1lc3b)53Nmz mutation (5 available)
Trp53^tm1Tyj mutation (12 available); any Trp53 mutation (239 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

abnormal heart morphology ( J:183674 )

increased cardiac muscle contractility ( J:183674 )

• following myocardial infarction

abnormal response to cardiac infarction ( J:183674 )

cellular

abnormal mitochondrial chromosome morphology ( J:183674 )

• following myocardial infarction, cardiac muscles exhibit decreased mitochondria DNA damage compared to in wild-type mice

• however, treatment with chloroquine elevates mitochondria DNA damage to wild-type levels

abnormal autophagy ( J:183674 )

• following myocardial infarction, autophagy in cardiac muscles is increased compared to in wild-type mice

decreased cardiomyocyte apoptosis ( J:183674 )

• following myocardial infarction

abnormal mitochondrial physiology ( J:183674 )

• following myocardial infarction, cardiac muscles exhibit increased mitophagy compared to in wild-type mice

• however, treatment with chloroquine elevates mitochondrial to wild-type levels

oxidative stress ( J:183674 )

• following myocardial infarction, cardiac muscles exhibit increased levels of reactive oxygen species production compared to in wild-type mice

homeostasis/metabolism

abnormal response to cardiac infarction ( J:183674 )

abnormal autophagy ( J:183674 )

• following myocardial infarction, autophagy in cardiac muscles is increased compared to in wild-type mice

muscle

increased cardiac muscle contractility ( J:183674 )

• following myocardial infarction

decreased cardiomyocyte apoptosis ( J:183674 )

• following myocardial infarction

Allelic Composition	Tsc2^tm1Djk/Tsc2⁺ Tg(CAG-EGFP/Map1lc3b)53Nmz/0
Genetic Background	involves: 129S4/SvJae * C57BL/6 * C57BL/6J * C57BL/6NCrlj * DBA/2

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(CAG-EGFP/Map1lc3b)53Nmz mutation (5 available)
Tsc2^tm1Djk mutation (1 available); any Tsc2 mutation (78 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

abnormal autophagosome formation ( J:217829 )

• failure of autophagosome induction in neurons

• rapamycin treatment normalizes autophagosome formation in neurons

homeostasis/metabolism

abnormal autophagosome formation ( J:217829 )

• failure of autophagosome induction in neurons

• rapamycin treatment normalizes autophagosome formation in neurons

Allelic Composition	Map1s^tm1.1Lliu/Map1s^tm1.1Lliu Tg(CAG-EGFP/Map1lc3b)53Nmz/0
Genetic Background	involves: 129S4/SvJaeSor * C57BL/6 * C57BL/6NCrj

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Map1s^tm1.1Lliu mutation (0 available); any Map1s mutation (37 available)
Tg(CAG-EGFP/Map1lc3b)53Nmz mutation (5 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

increased susceptibility to induced morbidity/mortality ( J:170757 )

• starved neonates survival time is half that of similarly treated wild-type mice

cellular

abnormal autophagy ( J:170757 )

• heart and liver tissues from pups under nutritive stress exhibit early accumulation of autophagosomes associated with impaired autophagosomal degradation compared with tissues form wild-type mice

homeostasis/metabolism

abnormal autophagy ( J:170757 )

• heart and liver tissues from pups under nutritive stress exhibit early accumulation of autophagosomes associated with impaired autophagosomal degradation compared with tissues form wild-type mice

Allelic Composition	Atg4d^{Gt(OST254045)Lex}/Atg4d^{Gt(OST254045)Lex} Tg(CAG-EGFP/Map1lc3b)53Nmz/0
Genetic Background	involves: 129S5/SvEvBrd * C57BL/6J * C57BL/6NCrlj * DBA/2J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atg4d^{Gt(OST254045)Lex} mutation (1 available); any Atg4d mutation (18 available)
Tg(CAG-EGFP/Map1lc3b)53Nmz mutation (5 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal Purkinje cell morphology ( J:313858 )

• misaligned and reduced size cell body with abnormally shaped nucleus and high numbers of autophagosomes

abnormal cerebellar molecular layer ( J:313858 )

• abnormal at 2 months persisting at 5 months

thin cerebellar molecular layer ( J:313858 )

• with reactive gliosis and synaptic clusters of GABA-A receptors

gliosis ( J:313858 )

• in the cerebellar molecular layer

neurodegeneration ( J:313858 )

• age-dependent cerebellar neurodegeneration

Purkinje cell degeneration ( J:313858 )

• in aged mice without increased apoptosis

behavior/neurological

impaired long-term object recognition memory ( J:313858 )

• impaired

increased thigmotaxis ( J:313858 )

limb grasping ( J:313858 )

• at 2 and 5 months, more pronounced with age

ataxia ( J:313858 )

• cerebellar ataxia

impaired coordination ( J:313858 )

• at 2 and 5 months of age on a rotarod and balance beam, more pronounced with age

decreased grip strength ( J:313858 )

• at 2 and 5 months, more pronounced with age

long stride length ( J:313858 )

• at 2 and 5 months, more pronounced with age

homeostasis/metabolism

abnormal autophagosome formation ( J:313858 )

• increased and smaller size GFP-LC3B+ structures in mouse embryonic fibroblasts

• increased ATG8-like proteins in GFP-LCB3 puncta in the liver, heart, and skeletal muscle of mice fed ad libitum or after 24 h fast

• however, autophagy flux is normal

cellular

abnormal autophagosome formation ( J:313858 )

• increased ATG8-like proteins in GFP-LCB3 puncta in the liver, heart, and skeletal muscle of mice fed ad libitum or after 24 h fast

• however, autophagy flux is normal

• increased and smaller size GFP-LC3B+ structures in mouse embryonic fibroblasts

Allelic Composition	Bcl2^tm1.1Sjk/Bcl2^tm1.1Sjk Tg(CAG-EGFP/Map1lc3b)53Nmz/0
Genetic Background	involves: 129X1/SvJ * C57BL/6 * C57BL/6NCrj * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bcl2^tm1.1Sjk mutation (1 available); any Bcl2 mutation (41 available)
Tg(CAG-EGFP/Map1lc3b)53Nmz mutation (5 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

impaired exercise endurance ( J:181308 )

• decreased exercise endurance

impaired autophagy ( J:181308 )

• reduced in starved mouse embryonic fibroblasts and skeletal and cardiac muscles or skeletal muscles from exercised mice

• however, basal levels of autophagy are normal

increased circulating leptin level ( J:181308 )

• in mice fed a high-fat diet with no drop in levels following exercise unlike in wild-type mice

abnormal carbon dioxide production ( J:181308 )

• exercised mice fed a high-fat diet fail to exhibit an increase in carbon dioxide production unlike wild-type mice

abnormal oxygen consumption ( J:181308 )

• exercised mice fed a high-fat diet fail to exhibit an increase in oxygen consumption unlike wild-type mice

abnormal glucose homeostasis ( J:181308 )

• mice exhibit impaired exercise-induced increase in insulin sensitivity compared with wild-type mice

abnormal circulating glucose level ( J:181308 )

• exercised mice fail to exhibit a decrease in circulating glucose levels compared with wild-type mice

abnormal circulating insulin level ( J:181308 )

• exercised mice exhibit less of a reduction in plasma insulin levels compared with wild-type mice

abnormal glucose tolerance ( J:181308 )

• exercised mice fed a high-fat diet fail to exhibit protection from impaired glucose tolerance compared with wild-type mice

• however, mice fed standard chow exhibit normal glucose tolerance

abnormal circulating adiponectin level ( J:181308 )

• exercised mice fed a high-fat diet fail to exhibit an increase in adiponectin levels unlike in wild-type mice

abnormal cholesterol homeostasis ( J:181308 )

• exercised mice fed a high-fat diet exhibit less of a decrease in cholesterol levels compared with wild-type mice

abnormal triglyceride level ( J:181308 )

• exercised mice fed a high-fat diet exhibit less of a decrease in triglyceride levels compared with wild-type mice

abnormal basal metabolism ( J:181308 )

• exercised mice fed a high-fat diet fail to exhibit an increase in heat production unlike wild-type mice

cellular

impaired autophagy ( J:181308 )

• reduced in starved mouse embryonic fibroblasts and skeletal and cardiac muscles or skeletal muscles from exercised mice

• however, basal levels of autophagy are normal

decreased skeletal muscle cell glucose uptake ( J:181308 )

• decreased 14C-deoxyglucose uptake in soleus muscle during treadmill exercise

adipose tissue

abnormal percent body fat/body weight ( J:181308 )

• exercised mice fed a high-fat diet exhibit less of a decrease in percent fat mass compared with wild-type mice

muscle

muscle phenotype ( J:181308 )

N	• baseline cardiac and skeletal muscle properties are normal

decreased skeletal muscle cell glucose uptake ( J:181308 )

• decreased 14C-deoxyglucose uptake in soleus muscle during treadmill exercise

behavior/neurological

impaired exercise endurance ( J:181308 )

• decreased exercise endurance

Allelic Composition	Dapk1^tm1Akc/Dapk1^tm1Akc Tg(CAG-EGFP/Map1lc3b)53Nmz/0
Genetic Background	involves: 129X1/SvJ * C57BL/6J * C57BL/6NCrj

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dapk1^tm1Akc mutation (0 available); any Dapk1 mutation (126 available)
Tg(CAG-EGFP/Map1lc3b)53Nmz mutation (5 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

abnormal cell morphology ( J:158109 )

• inhibited GFP-LC3 dots accumulation in embryonic fibroblasts (MEFs)

• reduced number of GFP-LC3 dots/mm2 in MEFs treated with thapsigargin for 24 h

Allelic Composition	Becn1^tm1Blev/Becn1⁺ Tg(CAG-EGFP/Map1lc3b)53Nmz/0
Genetic Background	involves: 129X1/SvJ * C57BL/6J * C57BL/6NCrj

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Becn1^tm1Blev mutation (1 available); any Becn1 mutation (36 available)
Tg(CAG-EGFP/Map1lc3b)53Nmz mutation (5 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

impaired autophagy ( J:86953 )

• mutants show decreased autophagy during starvation conditions in muscle and bronchial epithelial cells

homeostasis/metabolism

impaired autophagy ( J:86953 )

• mutants show decreased autophagy during starvation conditions in muscle and bronchial epithelial cells

Allelic Composition	Becn1^tm1Blev/Becn1⁺ Tg(CAG-EGFP/Map1lc3b)53Nmz/0
Genetic Background	involves: 129X1/SvJ * C57BL/6NCrj

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Becn1^tm1Blev mutation (1 available); any Becn1 mutation (36 available)
Tg(CAG-EGFP/Map1lc3b)53Nmz mutation (5 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

impaired autophagy ( J:181308 )

• reduced exercised-induced autophagy in skeletal muscles compared to in wild-type muscles

homeostasis/metabolism

impaired exercise endurance ( J:181308 )

• mice exhibit decreased maximal treadmill running distance compared with wild-type mice

impaired autophagy ( J:181308 )

• reduced exercised-induced autophagy in skeletal muscles compared to in wild-type muscles

behavior/neurological

impaired exercise endurance ( J:181308 )

• mice exhibit decreased maximal treadmill running distance compared with wild-type mice

Allelic Composition	Rubcn^em1Dgre/Rubcn^em1Dgre Tg(CAG-EGFP/Map1lc3b)53Nmz/0
Genetic Background	involves: C57BL/6 * C57BL/6J * C57BL/6N * C57BL/6NCrlj * DBA/2

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rubcn^em1Dgre mutation (1 available); any Rubcn mutation (40 available)
Tg(CAG-EGFP/Map1lc3b)53Nmz mutation (5 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

abnormal macrophage morphology ( J:261225 )

• increased numbers of LC3 (Map1lc3) puncta

abnormal macrophage physiology ( J:261225 )

• unable to translocate LC3 (Map1lc3) to LAP (LC3-associated phagocytosis)-engaged phagosome

• phagocytosis

immune system

abnormal macrophage morphology ( J:261225 )

• increased numbers of LC3 (Map1lc3) puncta

abnormal macrophage physiology ( J:261225 )

• unable to translocate LC3 (Map1lc3) to LAP (LC3-associated phagocytosis)-engaged phagosome

• phagocytosis

Allelic Composition	AA467197^em1Nyam/AA467197^em1Nyam Tg(CAG-EGFP/Map1lc3b)53Nmz/0
Genetic Background	involves: C57BL/6J * C57BL/6NCrlj * DBA/2

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
AA467197^em1Nyam mutation (0 available); any AA467197 mutation (6 available)
Tg(CAG-EGFP/Map1lc3b)53Nmz mutation (5 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

impaired autophagy ( J:347271 )

• autophagy is diminished in medullary thymic epithelial cells (mTECs) and is slightly, but significantly, reduced in cortical thymic epithelial cells (cTECs), indicating reduced stress-independent autophagy induction

• however, starvation-induced autophagy is not affected

homeostasis/metabolism

impaired autophagy ( J:347271 )

• however, starvation-induced autophagy is not affected

Allelic Composition	Sox2^tm1.2Lan/Sox2^tm1.2Lan Tg(CAG-EGFP/Map1lc3b)53Nmz/0
Genetic Background	involves: C57BL/6 * C57BL/6NCrlj * DBA/2 * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sox2^tm1.2Lan mutation (0 available); any Sox2 mutation (56 available)
Tg(CAG-EGFP/Map1lc3b)53Nmz mutation (5 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

abnormal autophagy ( J:205532 )

• impaired in embryonic cells

homeostasis/metabolism

abnormal autophagy ( J:205532 )

• impaired in embryonic cells

Allelic Composition	Rubcn^em1Dgre/Rubcn^em1Dgre Tg(CAG-EGFP/Map1lc3b)53Nmz/0
Genetic Background	involves: C57BL/6 * C57BL/6N * DBA/2

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rubcn^em1Dgre mutation (1 available); any Rubcn mutation (40 available)
Tg(CAG-EGFP/Map1lc3b)53Nmz mutation (5 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

abnormal macrophage physiology ( J:235399 )

homeostasis/metabolism

abnormal circulating chemokine level ( J:235399 )

• serum CCL4 levels are acutely increased in mice injected with UV-irradiated dying thymocytes

increased circulating interleukin-1 beta level ( J:235399 )

• serum IL-1beta levels are acutely increased in mice injected with UV-irradiated dying thymocytes

decreased circulating interleukin-10 level ( J:235399 )

• serum IL-10 levels are not increased in mutant mice injected with UV-irradiated dying thymocytes like in wild-type mice

increased circulating interleukin-6 level ( J:235399 )

• serum IL-6 levels are acutely increased in mice injected with UV-irradiated dying thymocytes

immune system

abnormal macrophage physiology ( J:235399 )

abnormal circulating chemokine level ( J:235399 )

• serum CCL4 levels are acutely increased in mice injected with UV-irradiated dying thymocytes

increased circulating interleukin-1 beta level ( J:235399 )

• serum IL-1beta levels are acutely increased in mice injected with UV-irradiated dying thymocytes

decreased circulating interleukin-10 level ( J:235399 )

• serum IL-10 levels are not increased in mutant mice injected with UV-irradiated dying thymocytes like in wild-type mice

increased circulating interleukin-6 level ( J:235399 )

• serum IL-6 levels are acutely increased in mice injected with UV-irradiated dying thymocytes

Allelic Composition	Glipr2^em1Blev/Glipr2^em1Blev Tg(CAG-EGFP/Map1lc3b)53Nmz/0
Genetic Background	involves: C57BL/6J * DBA/2

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Glipr2^em1Blev mutation (0 available); any Glipr2 mutation (37 available)
Tg(CAG-EGFP/Map1lc3b)53Nmz mutation (5 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

enhanced autophagy ( J:312370 )

• increased autophagosomes in all tissues examined, including heart, liver, and skeletal muscle due to increased autophagic flux

• however, autophagosome maturation is normal

homeostasis/metabolism

enhanced autophagy ( J:312370 )

• increased autophagosomes in all tissues examined, including heart, liver, and skeletal muscle due to increased autophagic flux

• however, autophagosome maturation is normal

Allelic Composition	Tg(CAG-EGFP/Map1lc3b)53Nmz/0 Tg(Myh6-Gsk3b*)19Jusa/0
Genetic Background	involves: C57BL/6NCrj * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(CAG-EGFP/Map1lc3b)53Nmz mutation (5 available)
Tg(Myh6-Gsk3b*)19Jusa mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

increased myocardial infarct size ( J:186597 )

• following 2 hours of ischemia without reperfusion

• however, treatment with rapamycin reduces infarct size

cellular

abnormal autophagy ( J:186597 )

• reduced autophagy in the heart following 2 hours of ischemia or ischemia with reperfusion

• however, treatment with rapamycin restores autophagy in both cases

homeostasis/metabolism

increased myocardial infarct size ( J:186597 )

• following 2 hours of ischemia without reperfusion

• however, treatment with rapamycin reduces infarct size

abnormal autophagy ( J:186597 )

• reduced autophagy in the heart following 2 hours of ischemia or ischemia with reperfusion

• however, treatment with rapamycin restores autophagy in both cases

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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