Phenotypes associated with this allele

• Allele Symbol: Mapkap1^tm1Bisu
• Allele Name: targeted mutation 1, Bing Su
• Allele ID: MGI:3759854
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mapkap1^tm1Bisu/Mapkap1^tm1Bisu	B6.129S7-Mapkap1^tm1Bisu	MGI:3759855

Genotype
MGI:3759855

hm1

• Allelic Composition: Mapkap1^tm1Bisu/Mapkap1^tm1Bisu
• Genetic Background: B6.129S7-Mapkap1^tm1Bisu

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

prenatal lethality, complete penetrance ( J:125618 )

• embryonic lethality occurs due to early developmental problems

cellular

increased cellular sensitivity to hydrogen peroxide ( J:125618 )

• when exposed to hydrogen peroxide mouse embryonic fibroblasts (MEFs) exhibit a 20% to 50% survival rate compared to a 70% to 100% survival rate for wild-type MEFs

increased fibroblast apoptosis ( J:125618 )

• when treated with etoposide, mouse embryonic fibroblasts (MEFs) undergo a 2-fold increase in apoptosis compared to wild-type MEFs