Phenotypes associated with this allele

• Allele Symbol: Adora2b^tm1Till
• Allele Name: targeted mutation 1, Stephen Tilley
• Allele ID: MGI:3759856
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Adora2b^tm1Till/Adora2b^tm1Till	B6.129P2-Adora2b^tm1Till	MGI:3759858

Genotype
MGI:3759858

hm1

• Allelic Composition: Adora2b^tm1Till/Adora2b^tm1Till
• Genetic Background: B6.129P2-Adora2b^tm1Till

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

increased susceptibility to induced morbidity/mortality ( J:125297 )

• 30% of mice die following antigen challenge whereas all wild-type mice survive the same treatment

immune system

abnormal cellular extravasation ( J:125297 )

• extravasation of mast cells in pinnae treated with 1 ug IgE is increased relative to in similarly treated wild-type ears

• however, no difference is observed in ears treated with 100 ug IgE

increased susceptibility to type I hypersensitivity reaction ( J:125297 )

• mice exhibit a more severe anaphylactic response at a 10-fold lower dose (2ug) of DNP IgE compared to wild-type mice

increased interleukin-6 secretion ( J:125297 )

• after incubation for 7 hours with antigen, bone marrow derived mast cells release higher amounts of IL-6 than do wild-type cells

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:125297 )

N • unlike in Adora2a null mice, blood pressure homeostasis is normal

impaired adaptive thermogenesis ( J:125297 )

• mice exhibit a greater temperature drop (4.6+/-0.24 compared to 3.7+/-0.29 degrees Celsius 10 minutes for wild-type mice after administration of 20 ug of DNP-HAS and 6.9+/-0.29 compared to 5.6+/-0.28 degrees Celsius 20 minutes for wild-type mice after administration of 20 ug of DNP-HAS)

decreased physiological sensitivity to xenobiotic ( J:125297 )

• treatment with 50 nM to 100 uM UVF5574 fails to inhibit antigen-induced degranulation of bone marrow derived mast cells

cellular

abnormal cellular extravasation ( J:125297 )

• extravasation of mast cells in pinnae treated with 1 ug IgE is increased relative to in similarly treated wild-type ears

• however, no difference is observed in ears treated with 100 ug IgE

hematopoietic system

abnormal cellular extravasation ( J:125297 )

• extravasation of mast cells in pinnae treated with 1 ug IgE is increased relative to in similarly treated wild-type ears

• however, no difference is observed in ears treated with 100 ug IgE