All Phenotypes Gab1<tm2Wbm> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Gab1^tm2Wbm/Gab1^tm2Wbm	involves: 129P2/OlaHsd * BALB/cJ * C57BL/6 * CD-1	MGI:3759970
ht2	Gab1^tm2Wbm/Gab1^tm3Wbm	involves: 129P2/OlaHsd * BALB/cJ * C57BL/6 * CD-1	MGI:3759968

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Placenta defect and small liver size in Gab1^tm3Wbm/Gab1^tm3Wbm, Gab1^tm2Wbm/Gab1^tm2Wbm and Gab1^tm2WbmGab1^tm3Wbm mice

mortality/aging

lethality throughout fetal growth and development, complete penetrance ( J:125303 )

• mice live up to E16 but are never born

embryo

abnormal placenta labyrinth morphology ( J:125303 )

• at E14.5, mice develop a thin and disorganized labyrinth layer

liver/biliary system

decreased liver weight ( J:125303 )

• at E14.5, the liver to body weight ratio is 5.5% compared to 8% in wild-type mice

craniofacial

palatal shelves fail to meet at midline ( J:125303 )

cleft secondary palate ( J:125303 )

• at E16, the secondary palate remains open in one third of mice

muscle

muscle phenotype ( J:125303 )

N	• unlike mice with other altered Gab1 alleles, emigration of muscle progenitors is comparable to in wild-type mice and limbs form normally

digestive/alimentary system

palatal shelves fail to meet at midline ( J:125303 )

cleft secondary palate ( J:125303 )

• at E16, the secondary palate remains open in one third of mice

growth/size/body

palatal shelves fail to meet at midline ( J:125303 )

cleft secondary palate ( J:125303 )

• at E16, the secondary palate remains open in one third of mice

Allelic Composition	Gab1^tm2Wbm/Gab1^tm3Wbm
Genetic Background	involves: 129P2/OlaHsd * BALB/cJ * C57BL/6 * CD-1

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gab1^tm2Wbm mutation (0 available); any Gab1 mutation (78 available)
Gab1^tm3Wbm mutation (0 available); any Gab1 mutation (78 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Placenta defect and small liver size in Gab1^tm3Wbm/Gab1^tm3Wbm, Gab1^tm2Wbm/Gab1^tm2Wbm and Gab1^tm2WbmGab1^tm3Wbm mice

embryo

thin placenta labyrinth ( J:125303 )

disorganized placental labyrinth ( J:125303 )

liver/biliary system

decreased liver weight ( J:125303 )

• at E14.5, the liver to body weight ratio is 5.5% compared to 8% in wild-type mice

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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