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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Gab1tm5Wbm
targeted mutation 5, Walter Birchmeier
MGI:3759868
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Gab1tm5Wbm/Gab1tm5Wbm involves: 129P2/OlaHsd * BALB/cJ * C57BL/6 * CD-1 MGI:3759965


Genotype
MGI:3759965
hm1
Allelic
Composition
Gab1tm5Wbm/Gab1tm5Wbm
Genetic
Background
involves: 129P2/OlaHsd * BALB/cJ * C57BL/6 * CD-1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gab1tm5Wbm mutation (0 available); any Gab1 mutation (78 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Placenta development and muscle progenitor cell migration are disturbed in Gab1tm5Wbm/Gab1tm5Wbm mice

mortality/aging
• mice only survive up to E12 when they are present in reduced ratios

embryo
• at E12.5, placental labyrinth is 40% thinner than in wild-type mice
• however, the spongiotrophoblast layer is well developed
• at E12.5, placental labyrinth appears less organized

cellular
• at E10.5, migratory cells in the limb bud or the hypoglossal stream are reduced compared to in wild-type mice

muscle
• muscle progenitor cells are 3 times less abundant and do not move as far distally as in wild-type mice
• muscle progenitor cells are 3 times less abundant and do not move as far distally as in wild-type mice
• at E12.5, muscle precursor cells are reduced in number relative to in wild-type mice





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory