Analysis Tools|
Allele Symbol Allele Name Allele ID |
Mapk8ip2tm1Rjd targeted mutation 1, Roger J Davis MGI:3759989 |
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| Summary |
4 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• NMDA-mediated current amplitude is decreased relative to in wild-type mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• within 2 weeks of birth
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| N |
• mice exhibit normal growth
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• at P2 and P10
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• at P10
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• severe
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| N |
• despite abnormal beta cell morphology, mice exhibit normal blood insulin concentration
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• beta cells exhibit fewer exocytotic vesicles compared with wild-type cells
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice exhibit defects in the cerebellum
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• mice have defects in arborization of Purkinje cell
• however, cortical and hippocampal neurons are normal
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• treatment with NMDA fails to cause an increase in cytoplasmic calcium in neurons unlike in wild-type mice
• NMDA-mediated current amplitude is decreased relative to in wild-type mice
• desensitization of the NMDA-mediated current is reduced relative to in wild-type mice
• however, intracellular calcium homeostasis is normal
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/12/2024 MGI 6.24 |
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