Phenotypes associated with this allele

• Allele Symbol: Wwtr1^tm1Benj
• Allele Name: targeted mutation 1, Thomas Benjamin
• Allele ID: MGI:3759999
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Wwtr1^tm1Benj/Wwtr1^tm1Benj	129S-Wwtr1^tm1Benj/J	MGI:4420930
hm2	Wwtr1^tm1Benj/Wwtr1^tm1Benj	129S6/SvEvTac-Wwtr1^tm1Benj	MGI:3760003

Genotype
MGI:4420930

hm1

• Allelic Composition: Wwtr1^tm1Benj/Wwtr1^tm1Benj
• Genetic Background: 129S-Wwtr1^tm1Benj/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:156586 )

• female mice usually succumb before breeding age

prenatal lethality, incomplete penetrance ( J:156586 )

• only 10% to 25% of the expected mice are born

reproductive system

reduced female fertility ( J:156586 )

♀ • successful breeding of female mice is uncommon

growth/size/body

polycystic kidney ( J:156586 )

• onset as early as a few weeks of age

decreased body size ( J:156586 )

enlarged kidney ( J:156586 )

• with age

behavior/neurological

decreased locomotor activity ( J:156586 )

renal/urinary system

polycystic kidney ( J:156586 )

• onset as early as a few weeks of age

enlarged kidney ( J:156586 )

• with age

respiratory system

lung inflammation ( J:156586 )

• in some mice

abnormal pulmonary alveolus wall morphology ( J:156586 )

• breakdown of alveolar walls

overexpanded pulmonary alveolus ( J:156586 )

• swollen alveoli

emphysema ( J:156586 )

• mice exhibit swollen alveoli and breakdown of alveolar walls

digestive/alimentary system

intestinal inflammation ( J:156586 )

• in some mice

immune system

intestinal inflammation ( J:156586 )

• in some mice

lung inflammation ( J:156586 )

• in some mice

adipose tissue

decreased fat cell size ( J:156586 )

Genotype
MGI:3760003

hm2

• Allelic Composition: Wwtr1^tm1Benj/Wwtr1^tm1Benj
• Genetic Background: 129S6/SvEvTac-Wwtr1^tm1Benj

mortality/aging

prenatal lethality, incomplete penetrance ( J:125326 )

• only half of the expected number of mice are born

renal/urinary system

kidney cortex cyst ( J:125326 )

• mice develop severe polycystic renal disease with cysts of varying sizes scattered throughout the cortex

• cysts are bilateral, appear at day 18 at the earliest, are lined with cuboidal epithelium with scanty cytoplasm and are frequently filled with homogeneous eosinopilic fluid or small amounts of floccular material

• cysts and kidney size increase with age

• however, mice do not develop cysts in the salivary glands, pancreas, liver or other glandular organs

polycystic kidney ( J:125326 )

• mice develop severe polycystic renal disease

enlarged kidney ( J:125326 )

• kidney size increases with age

hydronephrosis ( J:125326 )

• mice exhibit dilation of the renal pelvis at a young age

respiratory system

lung inflammation ( J:125326 )

• lung inflammation is observed in some 2- to 4-week old mice

abnormal pulmonary alveolus wall morphology ( J:125326 )

• breakdown of alveolar walls

overexpanded pulmonary alveolus ( J:125326 )

• swollen alveoli

emphysema ( J:125326 )

• mice develop emphysema associated with swollen alveoli and breakdown of alveolar walls

immune system

intestinal inflammation ( J:125326 )

• intestinal inflammation is observed in some 2- to 4-week old mice

lung inflammation ( J:125326 )

• lung inflammation is observed in some 2- to 4-week old mice

adipose tissue

decreased fat cell size ( J:125326 )

• adipocytes are smaller in size than in wild-type mice

behavior/neurological

decreased locomotor activity ( J:125326 )

growth/size/body

kidney cortex cyst ( J:125326 )

• mice develop severe polycystic renal disease with cysts of varying sizes scattered throughout the cortex

• cysts are bilateral, appear at day 18 at the earliest, are lined with cuboidal epithelium with scanty cytoplasm and are frequently filled with homogeneous eosinopilic fluid or small amounts of floccular material

• cysts and kidney size increase with age

• however, mice do not develop cysts in the salivary glands, pancreas, liver or other glandular organs

polycystic kidney ( J:125326 )

• mice develop severe polycystic renal disease

decreased body size ( J:125326 )

enlarged kidney ( J:125326 )

• kidney size increases with age

digestive/alimentary system

intestinal inflammation ( J:125326 )

• intestinal inflammation is observed in some 2- to 4-week old mice