Phenotypes associated with this allele

• Allele Symbol: Chn1^mfy
• Allele Name: miffy
• Allele ID: MGI:3760001
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Chn1^mfy/Chn1^mfy	involves: C57BL/6	MGI:3778070

Genotype
MGI:3778070

hm1

• Allelic Composition: Chn1^mfy/Chn1^mfy
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

decreased body weight ( J:125703 )

• during postnatal period, body weight and size are slightly smaller than heterozygous and wild-type controls, but difference is absent in adult animals

behavior/neurological

abnormal gait ( J:125703 )

• all mutants move left and right hindlimbs synchronously, resulting in a rabbit-like hopping gait

nervous system

abnormal cerebral cortex morphology ( J:125703 )

• ipsilateral motor cortex contains many corticospinal tract neurons, whereas in controls most CST neurons are located in layer V of the contralateral motor cortex

• cell count of motor cortex shows 34% more cells in the ipsilateral cortex compared to the contralateral cortex while controls only show a 2% increase in cell number

abnormal corticospinal tract morphology ( J:125703 )

• aberrant midline recrossing of corticospinal tract axons is observed in spinal cord of all mutants

• at P4, more neurons cross the midline relative to wild-type or heterozygous controls

abnormal spinal cord dorsal column morphology ( J:125703 )

• white matter in dorsal funiculus is reduced, most prominently at the lumbar levels

abnormal nervous system electrophysiology ( J:125703 )

• in spinal cords of P1-P3 animals, upon stimulation with NMDA and serotonin left and right lumbar 2 ventral root activity displays a synchronous rhythm in contrast to the alternating left and right activity exhibited by controls