Phenotypes associated with this allele

• Allele Symbol: Chn1^tm1.1Ito
• Allele Name: targeted mutation 1.1 Shigeyoshi Itohara
• Allele ID: MGI:3760002
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Chn1^tm1.1Ito/Chn1^tm1.1Ito	involves: C57BL/6NSlc	MGI:3778071
cn2	Chn1^tm1Ito/Chn1^tm1.1Ito Emx1^tm1(cre)Krj/Emx1^+	involves: 129S2/SvPas * C57BL/6NSlc	MGI:5614424
cn3	Chn1^tm1Ito/Chn1^tm1.1Ito Tg(Slc17a6-icre)1Oki/0	involves: C57BL/6 * C57BL/6NSlc	MGI:5614426

Genotype
MGI:3778071

hm1

• Allelic Composition: Chn1^tm1.1Ito/Chn1^tm1.1Ito
• Genetic Background: involves: C57BL/6NSlc

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal gait ( J:125703 , J:209606 )

• mice exhibit a hopping gait similar to Chn^mfy homozygotes (J:125703)

• quadrupedal hopping gait is dominant at all locomotor frequencies (J:209606)

• occasional alternating gait is seen at lower frequencies (J:209606)

nervous system

abnormal corticospinal tract morphology ( J:125703 )

• aberrant midline recrossing of corticospinal tract axons is observed

abnormal spinal cord morphology ( J:125703 , J:209606 )

• aberrant midline crossing of spinal local circuit neurons is seen (J:125703)

• significantly wider gap between the central canal and the ventral edge of the dorsal funiculus (J:209606)

abnormal spinal cord dorsal column morphology ( J:125703 )

• ventral extension of the dorsal funiculus is decreased

abnormal nervous system electrophysiology ( J:125703 )

• abnormal spinal central pattern generators, similar to Chn^mfy mice are seen in mutants

Genotype
MGI:5614424

cn2

• Allelic Composition: Chn1^tm1Ito/Chn1^tm1.1Ito; Emx1^tm1(cre)Krj/Emx1⁺
• Genetic Background: involves: 129S2/SvPas * C57BL/6NSlc

behavior/neurological

behavior/neurological phenotype ( J:209606 )

N • unlike in germ line null mice, the gait is similar to that in wild-type mice

Genotype
MGI:5614426

cn3

• Allelic Composition: Chn1^tm1Ito/Chn1^tm1.1Ito; Tg(Slc17a6-icre)1Oki/0
• Genetic Background: involves: C57BL/6 * C57BL/6NSlc

behavior/neurological

abnormal gait ( J:209606 )

• quadrupedal hopping gait is dominant at all locomotor frequencies

• occasional alternating gait is seen at lower frequencies, occurrence of alternating gait is increased compared to mice heterozygous for Epha4 ^tm1.1Bzh Epha4^tm1.2Bzh and hemizygous for Tg(Slc17a6-icre)1Oki

nervous system

abnormal spinal cord morphology ( J:209606 )

• significantly wider gap between the central canal and the ventral edge of the dorsal funiculus

abnormal nerve fiber response ( J:209606 )

• chemically and electrically stimulated locomotor-like activity in isolated spinal cord preparations induces a synchronous "hopping" locomotor-like activity rather than an alternating locomotor-like activity