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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Krt19tm1Alki
targeted mutation 1, Abraham L Kierszenbaum
MGI:3760085
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Krt19tm1Alki/Krt19tm1Alki involves: 129X1/SvJ * C57BL/6J MGI:3760087
ht2
 		Krt19tm1Alki/Krt19+ involves: 129X1/SvJ * C57BL/6J MGI:3760088


Genotype
MGI:3760087
hm1
Allelic
Composition		 Krt19tm1Alki/Krt19tm1Alki
Genetic
Background		 involves: 129X1/SvJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Krt19tm1Alki mutation (0 available); any Krt19 mutation (21 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Krt19tm1Alki/Krt19tm1Alki spermatids exhibit ectopic manchettes

reproductive system
abnormal sperm flagellum morphology ( J:125621 )
• 40% of epididymal sperm display normal head shape but tail abnormalities including hook- and U-shaped tails, sperm with shortened and thick tails, and conjoined sperm with hooked-shaped tails fused distally
• however, sperm display forward motility and axial rotation and random active particulate motion is observed in the residual cytoplasm
coiled sperm flagellum ( J:125621 )
• coiled flagella are observed in maturing spermatids and epididymal sperm of mutant mice
ectopic manchette ( J:125621 )
• 35% of round spermatids display ectopic manchette
transmission ratio distortion ( J:125621 )
• only 24% of offspring produced by intra cytoplasmic sperm injection retain the Krt19tm1Alki allele with the rest losing the neo cassette

cellular
abnormal sperm flagellum morphology ( J:125621 )
• 40% of epididymal sperm display normal head shape but tail abnormalities including hook- and U-shaped tails, sperm with shortened and thick tails, and conjoined sperm with hooked-shaped tails fused distally
• however, sperm display forward motility and axial rotation and random active particulate motion is observed in the residual cytoplasm
coiled sperm flagellum ( J:125621 )
• coiled flagella are observed in maturing spermatids and epididymal sperm of mutant mice
ectopic manchette ( J:125621 )
• 35% of round spermatids display ectopic manchette




Genotype
MGI:3760088
ht2
Allelic
Composition		 Krt19tm1Alki/Krt19+
Genetic
Background		 involves: 129X1/SvJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Krt19tm1Alki mutation (0 available); any Krt19 mutation (21 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Spermatid and epididymal sperm tail abnormalities in Krt19tm1Alki/Krt19tm1Alki and Krt19tm1Alki/Krt19+ mice

reproductive system
abnormal sperm flagellum morphology ( J:125621 )
• 40% of epididymal sperm display normal head shape but tail abnormalities including hook- and U-shaped tails, sperm with shortened and thick tails, and conjoined sperm with hooked-shaped tails fused distally
• however, sperm display forward motility and axial rotation and random active particulate motion is observed in the residual cytoplasm
coiled sperm flagellum ( J:125621 )
• coiled flagella are observed in maturing spermatids and epididymal sperm of mutant mice
ectopic manchette ( J:125621 )
• 35% of round spermatids display ectopic manchette

cellular
abnormal sperm flagellum morphology ( J:125621 )
• 40% of epididymal sperm display normal head shape but tail abnormalities including hook- and U-shaped tails, sperm with shortened and thick tails, and conjoined sperm with hooked-shaped tails fused distally
• however, sperm display forward motility and axial rotation and random active particulate motion is observed in the residual cytoplasm
coiled sperm flagellum ( J:125621 )
• coiled flagella are observed in maturing spermatids and epididymal sperm of mutant mice
ectopic manchette ( J:125621 )
• 35% of round spermatids display ectopic manchette




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
10/29/2024
MGI 6.24 		The Jackson Laboratory