Phenotypes associated with this allele

• Allele Symbol: Actn3^tm1Knno
• Allele Name: targeted mutation 1, Kathryn N North
• Allele ID: MGI:3760255
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Actn3^tm1Knno/Actn3^tm1Knno	involves: 129 * 129S1/Sv * 129X1/SvJ	MGI:3760256

Genotype
MGI:3760256

hm1

• Allelic Composition: Actn3^tm1Knno/Actn3^tm1Knno
• Genetic Background: involves: 129 * 129S1/Sv * 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

muscle

abnormal skeletal muscle morphology ( J:125639 )

• fast muscle fibers exhibit an increase in mitochondria density compared to wild-type

abnormal muscle physiology ( J:125639 )

• fast muscle fibers exhibit more staining for two markers of aerobic metabolism (NADH-tetrazolium reductase and succinate dehydroganse) compared to wild-type mice

• however, the increase in oxidative enzyme activity does not result in the loss of fast muscle fibers

• fast muscle metabolism is shifted from anaerobic to aerobic as determined by pyruvate metabolism enzyme activity

homeostasis/metabolism

increased aerobic running capacity ( J:125639 )

• when run until exhaustion, mice run 33% further than wild-type mice