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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(Tcra51-11.5,Tcrb51-11.5)AR206Ayr
transgene insertion AR206, Alexander Y Rudensky
MGI:3760401
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
 		Rag2tm1Fwa/Rag2tm1Fwa
Tg(Tcra51-11.5,Tcrb51-11.5)AR206Ayr/0 		involves: 129S/SvEv * C57BL/6 * C57BL/6NTac * DBA/2 MGI:3760859
tg2
 		Tg(Tcra51-11.5,Tcrb51-11.5)AR206Ayr/0 involves: C57BL/6 * DBA/2 MGI:3760858


Genotype
MGI:3760859
cx1
Allelic
Composition		 Rag2tm1Fwa/Rag2tm1Fwa
Tg(Tcra51-11.5,Tcrb51-11.5)AR206Ayr/0
Genetic
Background		 involves: 129S/SvEv * C57BL/6 * C57BL/6NTac * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rag2tm1Fwa mutation (48 available); any Rag2 mutation (119 available)
Tg(Tcra51-11.5,Tcrb51-11.5)AR206Ayr mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
thymus hyperplasia ( J:125548 )
• thymic cellularity is ~2-fold higher than in Rag2-sufficient transgenic mice
abnormal CD4-positive T cell differentiation ( J:125548 )
• rate of CD4+ T cell development is delayed by ~1 day relative to transgenic Rag2-sufficient animals
increased double-positive T cell number ( J:125548 )
• accumulation of CD4+CD8+ thymocytes is observed
decreased CD4-positive, alpha-beta T cell number ( J:125548 )
• CD4 single-positive thymocytes were reduced by >50% compared to Rag2-wild-type transgenic animals

hematopoietic system
thymus hyperplasia ( J:125548 )
• thymic cellularity is ~2-fold higher than in Rag2-sufficient transgenic mice
abnormal CD4-positive T cell differentiation ( J:125548 )
• rate of CD4+ T cell development is delayed by ~1 day relative to transgenic Rag2-sufficient animals
increased double-positive T cell number ( J:125548 )
• accumulation of CD4+CD8+ thymocytes is observed
decreased CD4-positive, alpha-beta T cell number ( J:125548 )
• CD4 single-positive thymocytes were reduced by >50% compared to Rag2-wild-type transgenic animals

endocrine/exocrine glands
thymus hyperplasia ( J:125548 )
• thymic cellularity is ~2-fold higher than in Rag2-sufficient transgenic mice




Genotype
MGI:3760858
tg2
Allelic
Composition		 Tg(Tcra51-11.5,Tcrb51-11.5)AR206Ayr/0
Genetic
Background		 involves: C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Tcra51-11.5,Tcrb51-11.5)AR206Ayr mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal positive T cell selection ( J:125548 )
• positive selection of CD4+ T cells is significantly reduced in the thymus compared to other lines

immune system
abnormal positive T cell selection ( J:125548 )
• positive selection of CD4+ T cells is significantly reduced in the thymus compared to other lines




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Send questions and comments to User Support. 		last database update
07/05/2024
MGI 6.24 		The Jackson Laboratory