All Phenotypes Tg(CD74)AR194Ayr MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Tg(CD74)AR194Ayr
transgene insertion AR194, Alexander Y Rudensky
MGI:3760406

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Cd74^tm1Liz/Cd74^tm1Liz H2-DMa^tm1Luc/H2-DMa^tm1Luc Tg(CD74)AR194Ayr/?	involves: 129S/SvEv * 129S4/SvJae * C57BL/6J * DBA/2J	MGI:3760430
tg2	Tg(CD74)AR194Ayr/?	B6.Cg-Tg(CD74)AR194Ayr	MGI:3760408

Allelic Composition	Cd74^tm1Liz/Cd74^tm1Liz H2-DMa^tm1Luc/H2-DMa^tm1Luc Tg(CD74)AR194Ayr/?
Genetic Background	involves: 129S/SvEv * 129S4/SvJae * C57BL/6J * DBA/2J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd74^tm1Liz mutation (4 available); any Cd74 mutation (36 available)
H2-DMa^tm1Luc mutation (1 available); any H2-DMa mutation (27 available)
Tg(CD74)AR194Ayr mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased CD4-positive, alpha-beta T cell number ( J:88717 )

• the number of CD4+ T cells is reduced to levels below wild-type but similar to those observed in Cd74^tm1Liz H2-DMa^tm1Luc homozygotes

abnormal antigen presentation via MHC class II ( J:88717 )

• unlike in wild-type cells, splenocytes are unable to elicit presentation of MHC class II exogenous antigens or of two endogenous antigens (IgM and beta-2 microglobulin)

• however, Tg(CD74)AR194Ayr completely rescues the MHC class II peptide loading observed in Cd74^tm1Liz H2-DMa^tm1Luc homozygotes and presentation of endogenous antigens for CD22 is normal

• after incubation with Ealpha peptide, loading of MHC class II is less than on similarly treated Cd74^tm1Liz H2-DMa^tm1Luc Tg(CD74*)AR194Ayr splenocytes

hematopoietic system

decreased CD4-positive, alpha-beta T cell number ( J:88717 )

• the number of CD4+ T cells is reduced to levels below wild-type but similar to those observed in Cd74^tm1Liz H2-DMa^tm1Luc homozygotes

Allelic Composition	Tg(CD74)AR194Ayr/?
Genetic Background	B6.Cg-Tg(CD74)AR194Ayr

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(CD74)AR194Ayr mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:88717 )

• hemizygotes are viable and fertile and do not display any gross physical or behavioral abnormalities

• when crossed with invariant chain targeted mice, they act as controls for other human invariant chain mutant transgenic lines

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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