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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Rapgef6tm1.1Tkat
targeted mutation 1.1, Tohru Kataoka
MGI:3760543
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Rapgef6tm1.1Tkat/Rapgef6tm1.1Tkat involves: 129P2/OlaHsd MGI:5620462
hm2
 		Rapgef6tm1.1Tkat/Rapgef6tm1.1Tkat involves: 129P2/OlaHsd * C57BL/6 MGI:3760621


Genotype
MGI:5620462
hm1
Allelic
Composition		 Rapgef6tm1.1Tkat/Rapgef6tm1.1Tkat
Genetic
Background		 involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rapgef6tm1.1Tkat mutation (2 available); any Rapgef6 mutation (110 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
oligozoospermia ( J:218581 )
• lower epididymal sperm concentration, with a decrease in the number of germ cells per seminiferous tubule at stage II, VII, and XI of spermatogenesis
abnormal sperm head morphology ( J:218581 )
• sperm exhibit a rounder shaped head
asthenozoospermia ( J:218581 )
• sperm motility rates are lower

reproductive system
asthenozoospermia ( J:218581 )
• sperm motility rates are lower
abnormal seminiferous tubule morphology ( J:218581 )
• enlargement of lumens in the seminiferous tubules
abnormal spermatogenesis ( J:218581 )
• severe hypospermatogenesis
oligozoospermia ( J:218581 )
• lower epididymal sperm concentration, with a decrease in the number of germ cells per seminiferous tubule at stage II, VII, and XI of spermatogenesis
abnormal sperm head morphology ( J:218581 )
• sperm exhibit a rounder shaped head
reduced male fertility ( J:218581 )
• successful mating rates with wild-type females and the number of fetuses resulting are lower

hematopoietic system

endocrine/exocrine glands
abnormal seminiferous tubule morphology ( J:218581 )
• enlargement of lumens in the seminiferous tubules

immune system

homeostasis/metabolism
homeostasis/metabolism phenotype ( J:218581 )
N
• mice exhibit normal follicle-stimulating hormone, luteinizing hormone, and testosterone serum levels

growth/size/body
enlarged spleen ( J:218581 )




Genotype
MGI:3760621
hm2
Allelic
Composition		 Rapgef6tm1.1Tkat/Rapgef6tm1.1Tkat
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rapgef6tm1.1Tkat mutation (2 available); any Rapgef6 mutation (110 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
enlarged spleen ( J:126164 )
• mice exhibit enlarged spleen compared to wild-type mice
• however, no defects in spleen histology are observed

cellular
abnormal cell adhesion ( J:126164 )
• TNF-alpha-stimulated adhesion in splenocytes is reduced relative to in wild-type cells
• however, PMA-stimulated adhesion in splenocytes and TNF-alpha- and PMA-stimulated adhesion thymocytes are normal LFA-1 mediated adhesion to ICAM-1 in splenocytes but not thymocytes is impaired

hematopoietic system
enlarged spleen ( J:126164 )
• mice exhibit enlarged spleen compared to wild-type mice
• however, no defects in spleen histology are observed

growth/size/body
enlarged spleen ( J:126164 )
• mice exhibit enlarged spleen compared to wild-type mice
• however, no defects in spleen histology are observed




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory