Analysis Tools
immune system
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• at 4 months of age, IgE levels are elevated relative to in wild-type mice
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• at 4 months of age, IgG1 and IgG2a levels are elevated relative to in wild-type mice
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• bone marrow-derived macrophages cultured in the absence of LPS produce more monocyte chemoattractant protein-1 and soluble TNF receptor I than wild-type cells
• bone marrow-derived macrophages cultured in the presence of LPS produce less IFN-insoluble T cell alpha chemoattractant, T cell activation-3 and tissue inhibitor of metalloproteinases-1 than wild-type cells
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• at 4 months of age, autoantibodies are increased specifically in the papillary layers of the corium where the inflammation starts to develop
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• mice develop edematous or bulbous inflammation on individual toes that progresses to further toes, palmar or plantar regions and other extremities
• inflamed areas are erythematous, scaly, or ulcerated and often ooze then form crusts
• at advanced stages toes adhere and osteolysis sets in followed by necrosis within extremities
• Background Sensitivity: 98% with a mean age of onset of 42.2+/-4 days on a C3H background and 52% (124+/-92 days) on a C3H C57BL/6 background develop skin inflammation
• inflammatory infiltrate of the dermis contains polymorphonuclear cells, plasma cells, and small lymphocytes
macrophages accumulate in the interphalangeal regions of the paws and thickened ear dermis
• ear are thick and hyperkeratotic with acanthotic epidermis and increased macrophage infiltration
• however, granulocyte accumulation is not observed in early lesions and injection of clodronate intraperitoneally and subcutaneously in paws (depleting peripheral blood monocytes and peritoneal macrophages) reduces frequency (12 paws compared to 32 in controls), time of onset and severity of inflammation
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hearing/vestibular/ear
thick ears
(
J:125785
)
skeleton
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• at advanced stages osteolysis of the phalangeal bones and interphalangeal articulations are observed
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cellular
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• following the development of osteolysis, necrosis is observed within extremities
• ears also develop ulcerations followed by necrosis
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limbs/digits/tail
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• at advanced stages osteolysis of the phalangeal bones and interphalangeal articulations are observed
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craniofacial
thick ears
(
J:125785
)
integument
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• mice develop edematous or bulbous inflammation on individual toes that progresses to further toes, palmar or plantar regions and other extremities
• inflamed areas are erythematous, scaly, or ulcerated and often ooze then form crusts
• at advanced stages toes adhere and osteolysis sets in followed by necrosis within extremities
• Background Sensitivity: 98% with a mean age of onset of 42.2+/-4 days on a C3H background and 52% (124+/-92 days) on a C3H C57BL/6 background develop skin inflammation
• inflammatory infiltrate of the dermis contains polymorphonuclear cells, plasma cells, and small lymphocytes
macrophages accumulate in the interphalangeal regions of the paws and thickened ear dermis
• ear are thick and hyperkeratotic with acanthotic epidermis and increased macrophage infiltration
• however, granulocyte accumulation is not observed in early lesions and injection of clodronate intraperitoneally and subcutaneously in paws (depleting peripheral blood monocytes and peritoneal macrophages) reduces frequency (12 paws compared to 32 in controls), time of onset and severity of inflammation
|
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• ear are thick and hyperkeratotic with acanthotic epidermis and increased macrophage infiltration
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acanthosis
(
J:125785
)
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• ear are thick and hyperkeratotic with acanthotic epidermis and increased macrophage infiltration
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reddish skin
(
J:125785
)
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• areas of skin inflammation are erythematous
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scaly skin
(
J:125785
)
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• areas of skin inflammation are scaly
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hematopoietic system
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• at 4 months of age, IgE levels are elevated relative to in wild-type mice
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• at 4 months of age, IgG1 and IgG2a levels are elevated relative to in wild-type mice
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growth/size/body
thick ears
(
J:125785
)
