Phenotypes associated with this allele

• Allele Symbol: Map3k12^{Gt(RRN366)Byg}
• Allele Name: gene trap RRN366, BayGenomics
• Allele ID: MGI:3760641
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Map3k12^Gt(RRN366)Byg/Map3k12^Gt(RRN366)Byg	involves: 129P2/OlaHsd * C57BL/6	MGI:3760659
hm2	Map3k12^Gt(RRN366)Byg/Map3k12^Gt(RRN366)Byg	involves: 129P2/OlaHsd * C57BL/6J	MGI:5440726
cx3	Map3k12^Gt(RRN366)Byg/Map3k12^Gt(RRN366)Byg Mycbp2^tm1.1Adia/Mycbp2^tm1.1Adia	involves: 129P2/OlaHsd * C57BL/6 * FVB/N	MGI:3760660

Genotype
MGI:3760659

hm1

• Allelic Composition: Map3k12^{Gt(RRN366)Byg}/Map3k12^{Gt(RRN366)Byg}
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

absent anterior commissure ( J:125702 )

• mice lack the anterior commissure

• however, the brain internal capsule is present

Genotype
MGI:5440726

hm2

• Allelic Composition: Map3k12^{Gt(RRN366)Byg}/Map3k12^{Gt(RRN366)Byg}
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

nervous system

slow Wallerian degeneration ( J:188476 )

• in vitro and in vivo

homeostasis/metabolism

slow Wallerian degeneration ( J:188476 )

• in vitro and in vivo

Genotype
MGI:3760660

cx3

• Allelic Composition: Map3k12^{Gt(RRN366)Byg}/Map3k12^{Gt(RRN366)Byg}; Mycbp2^tm1.1Adia/Mycbp2^tm1.1Adia
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

nervous system

abnormal nervous system morphology ( J:125702 )

• authors state that mice exhibit the same gross morphological defects as observed in Phr1^tm1.1Adia homozygotes

dilated lateral ventricle ( J:125702 )

• lateral ventricles are increased in size

abnormal brain internal capsule morphology ( J:125702 )

• mice lack the axon tract that runs through the internal capsule

absent brain internal capsule ( J:125702 )