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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ightm1.1Rsky
targeted mutation 1.1, Klaus Rajewsky
MGI:3760655
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Ightm1.1Rsky/Ightm1.1Rsky BALB/c-Ightm1.1Rsky MGI:3760852


Genotype
MGI:3760852
hm1
Allelic
Composition		 Ightm1.1Rsky/Ightm1.1Rsky
Genetic
Background		 BALB/c-Ightm1.1Rsky
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ightm1.1Rsky mutation (0 available); any Igh mutation (44 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal class switch recombination ( J:125719 )
• All mature B cells express the membrane form of IgM
decreased IgM level ( J:125719 )
• No IgM is detectable in the serum despite all mature B cells expressing surface IgM

hematopoietic system
abnormal class switch recombination ( J:125719 )
• All mature B cells express the membrane form of IgM
decreased IgM level ( J:125719 )
• No IgM is detectable in the serum despite all mature B cells expressing surface IgM




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory