All Phenotypes Igh<tm1.2Rsky> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Igh^tm1.2Rsky
targeted mutation 1.2, Klaus Rajewsky
MGI:3760662

Summary

10 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Igh^tm1.2Rsky/Igh^tm1.2Rsky	BALB/c-Igh^tm1.2Rsky	MGI:3760850
ht2	Igh^tm1.2Rsky/Igh⁺	BALB/c-Igh^tm1.2Rsky	MGI:3760849
cn3	Igh^tm1.2Rsky/Igh^tm1.2Rsky Tg(CD19-cre/ERT2)1Cgn/?	involves: BALB/c	MGI:3760857
cx4	Cd22^tm1Lam/Cd22^tm1Lam Igh^tm1.2Rsky/Igh^tm1.2Rsky	involves: 129 * BALB/c * C57BL/6	MGI:3760847
cx5	Cd79a^tm5.1Cgn/Cd79a⁺ Igh^tm1.2Rsky/Igh⁺	involves: 129 * BALB/c * C57BL/6	MGI:3760853
cx6	Cd79a^tm5.1Cgn/Cd79a^tm5.1Cgn Igh^tm1.2Rsky/Igh⁺	involves: 129 * BALB/c * C57BL/6	MGI:3760854
cx7	Cd79a^tm5.1Cgn/Cd79a^tm5.1Cgn Igh^tm1.2Rsky/Igh^tm1.2Rsky	involves: 129 * BALB/c * C57BL/6	MGI:3760855
cx8	Cd22^tm1Lam/Cd22^tm1Lam Igh^tm1.2Rsky/Igh⁺	involves: 129 * BALB/c * C57BL/6	MGI:3760862
cx9	Cd79a^tm4.1Cgn/Cd79a^tm4.1Cgn Igh^tm1.2Rsky/Igh⁺	involves: BALB/c * C57BL/6	MGI:3760848
cx10	Igh^tm1.2Rsky/Igh⁺ Tnfrsf13c^tm1Mass/Tnfrsf13c^tm1Mass	involves: BALB/c * C57BL/6	MGI:3760856

Allelic Composition	Igh^tm1.2Rsky/Igh^tm1.2Rsky
Genetic Background	BALB/c-Igh^tm1.2Rsky

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igh^tm1.2Rsky mutation (0 available); any Igh mutation (44 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal B cell morphology ( J:125719 )

decreased transitional stage B cell number ( J:125719 )

• one third less T1 B cells in the spleen

increased pro-B cell number ( J:125719 )

• about 2 fold increase due to a partial block in development from pro-B cell to pre-B cell

decreased pre-B cell number ( J:125719 )

• one third less pre-B cells exist in the bone marrow

abnormal mature B cell morphology ( J:125719 )

• B cells express lower levels of tnfrsf13c (BAFF receptor)

decreased B-1a cell number ( J:125719 )

• 5 fold reduction in the peritoneum

increased marginal zone B cell number ( J:125719 )

• there is a two to three fold increase in the spleen

abnormal B cell activation ( J:125719 )

• enhanced Ca²⁺ mobilization upon activation of B cells

abnormal B cell proliferation ( J:125719 )

• the half life of circulating B cells is 50% longer than in wild-type mice

decreased immunoglobulin level ( J:125719 )

decreased IgA level ( J:125719 )

• B cells only express IgG1

decreased IgD level ( J:125719 )

• B cells only express IgG1

decreased IgE level ( J:125719 )

• B cells only express IgG1

decreased IgM level ( J:125719 )

• B cells only express IgG1

hematopoietic system

abnormal B cell morphology ( J:125719 )

decreased transitional stage B cell number ( J:125719 )

• one third less T1 B cells in the spleen

increased pro-B cell number ( J:125719 )

• about 2 fold increase due to a partial block in development from pro-B cell to pre-B cell

decreased pre-B cell number ( J:125719 )

• one third less pre-B cells exist in the bone marrow

abnormal mature B cell morphology ( J:125719 )

• B cells express lower levels of tnfrsf13c (BAFF receptor)

decreased B-1a cell number ( J:125719 )

• 5 fold reduction in the peritoneum

increased marginal zone B cell number ( J:125719 )

• there is a two to three fold increase in the spleen

abnormal B cell activation ( J:125719 )

• enhanced Ca²⁺ mobilization upon activation of B cells

abnormal B cell proliferation ( J:125719 )

• the half life of circulating B cells is 50% longer than in wild-type mice

decreased immunoglobulin level ( J:125719 )

decreased IgA level ( J:125719 )

• B cells only express IgG1

decreased IgD level ( J:125719 )

• B cells only express IgG1

decreased IgE level ( J:125719 )

• B cells only express IgG1

decreased IgM level ( J:125719 )

• B cells only express IgG1

cellular

abnormal B cell proliferation ( J:125719 )

• the half life of circulating B cells is 50% longer than in wild-type mice

Allelic Composition	Igh^tm1.2Rsky/Igh⁺
Genetic Background	BALB/c-Igh^tm1.2Rsky

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igh^tm1.2Rsky mutation (0 available); any Igh mutation (44 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

increased IgG1 level ( J:125719 )

• 13% of B cells in the spleen express IgG1 opposed to less than 1% for wild-type mice

hematopoietic system

increased IgG1 level ( J:125719 )

• 13% of B cells in the spleen express IgG1 opposed to less than 1% for wild-type mice

Allelic Composition	Igh^tm1.2Rsky/Igh^tm1.2Rsky Tg(CD19-cre/ERT2)1Cgn/?
Genetic Background	involves: BALB/c

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igh^tm1.2Rsky mutation (0 available); any Igh mutation (44 available)
Tg(CD19-cre/ERT2)1Cgn mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal class switch recombination ( J:125719 )

• upon tamoxifen treatment, B cells switch immunoglobulin expression from IgG1 to IgM

abnormal B cell activation ( J:125719 )

• enhanced Ca²⁺ mobilization upon activation of B cells

hematopoietic system

abnormal class switch recombination ( J:125719 )

• upon tamoxifen treatment, B cells switch immunoglobulin expression from IgG1 to IgM

abnormal B cell activation ( J:125719 )

• enhanced Ca²⁺ mobilization upon activation of B cells

Allelic Composition	Cd22^tm1Lam/Cd22^tm1Lam Igh^tm1.2Rsky/Igh^tm1.2Rsky
Genetic Background	involves: 129 * BALB/c * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd22^tm1Lam mutation (1 available); any Cd22 mutation (64 available)
Igh^tm1.2Rsky mutation (0 available); any Igh mutation (44 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased B-1a cell number ( J:125719 )

• 5 fold reduction in the peritoneum

abnormal B cell activation ( J:125719 )

• enhanced Ca²⁺ mobilization to high levels upon activation of B cells

hematopoietic system

decreased B-1a cell number ( J:125719 )

• 5 fold reduction in the peritoneum

abnormal B cell activation ( J:125719 )

• enhanced Ca²⁺ mobilization to high levels upon activation of B cells

Allelic Composition	Cd79a^tm5.1Cgn/Cd79a⁺ Igh^tm1.2Rsky/Igh⁺
Genetic Background	involves: 129 * BALB/c * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd79a^tm5.1Cgn mutation (0 available); any Cd79a mutation (24 available)
Igh^tm1.2Rsky mutation (0 available); any Igh mutation (44 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

abnormal class switch recombination ( J:125719 )

• slight increase in the percentage of B cells expressing IgG1

immune system

abnormal class switch recombination ( J:125719 )

• slight increase in the percentage of B cells expressing IgG1

Allelic Composition	Cd79a^tm5.1Cgn/Cd79a^tm5.1Cgn Igh^tm1.2Rsky/Igh⁺
Genetic Background	involves: 129 * BALB/c * C57BL/6

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

abnormal class switch recombination ( J:125719 )

• increased percentage of B cells expressing IgG1 in the bone marrow and spleen compared to mutant mice with a wild-type Igalpha allele

immune system

abnormal class switch recombination ( J:125719 )

• increased percentage of B cells expressing IgG1 in the bone marrow and spleen compared to mutant mice with a wild-type Igalpha allele

Allelic Composition	Cd79a^tm5.1Cgn/Cd79a^tm5.1Cgn Igh^tm1.2Rsky/Igh^tm1.2Rsky
Genetic Background	involves: 129 * BALB/c * C57BL/6

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased T cell number ( J:125719 )

• 2 fold decrease in the number of T cells in the spleen

abnormal B cell morphology ( J:125719 )

abnormal class switch recombination ( J:125719 )

• more than a five fold increase in the percentage of B cells expressing IgG1

decreased immature B cell number ( J:125719 )

• less than 1 percent of bone marrow cells are immature B cells ( normal is about 8%)

increased pro-B cell number ( J:125719 )

• about 2 fold increase due to block in development from pro-B cell to pre-B cell

decreased mature B cell number ( J:125719 )

• 10 fold decrease in the number of B cells in the spleen

• 6 fold decrease in the number of B cells in the peritoneal cavity

• these numbers are higher than mice that are only null for Igalpha expression

increased B-1b cell number ( J:125719 )

• increased both in the spleen and peritoneal cavity

decreased pre-B cell number ( J:125719 )

• very few pre-B cells exist in the bone marrow

hematopoietic system

decreased T cell number ( J:125719 )

• 2 fold decrease in the number of T cells in the spleen

abnormal B cell morphology ( J:125719 )

abnormal class switch recombination ( J:125719 )

• more than a five fold increase in the percentage of B cells expressing IgG1

decreased immature B cell number ( J:125719 )

• less than 1 percent of bone marrow cells are immature B cells ( normal is about 8%)

increased pro-B cell number ( J:125719 )

• about 2 fold increase due to block in development from pro-B cell to pre-B cell

decreased mature B cell number ( J:125719 )

• 10 fold decrease in the number of B cells in the spleen

• 6 fold decrease in the number of B cells in the peritoneal cavity

• these numbers are higher than mice that are only null for Igalpha expression

increased B-1b cell number ( J:125719 )

• increased both in the spleen and peritoneal cavity

decreased pre-B cell number ( J:125719 )

• very few pre-B cells exist in the bone marrow

Allelic Composition	Cd22^tm1Lam/Cd22^tm1Lam Igh^tm1.2Rsky/Igh⁺
Genetic Background	involves: 129 * BALB/c * C57BL/6

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal class switch recombination ( J:125719 )

• the percentage of B cells with surface IgG1 expression is doubled compared to mutant mice on a CD22-proficient background

hematopoietic system

abnormal class switch recombination ( J:125719 )

• the percentage of B cells with surface IgG1 expression is doubled compared to mutant mice on a CD22-proficient background

Allelic Composition	Cd79a^tm4.1Cgn/Cd79a^tm4.1Cgn Igh^tm1.2Rsky/Igh⁺
Genetic Background	involves: BALB/c * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd79a^tm4.1Cgn mutation (1 available); any Cd79a mutation (24 available)
Igh^tm1.2Rsky mutation (0 available); any Igh mutation (44 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal pro-B cell differentiation ( J:125719 )

• B cells do not develop past this stage

hematopoietic system

abnormal pro-B cell differentiation ( J:125719 )

• B cells do not develop past this stage

Allelic Composition	Igh^tm1.2Rsky/Igh⁺ Tnfrsf13c^tm1Mass/Tnfrsf13c^tm1Mass
Genetic Background	involves: BALB/c * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igh^tm1.2Rsky mutation (0 available); any Igh mutation (44 available)
Tnfrsf13c^tm1Mass mutation (1 available); any Tnfrsf13c mutation (15 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased mature B cell number ( J:125719 )

• four fold reduction of mature B cells in the spleen

hematopoietic system

decreased mature B cell number ( J:125719 )

• four fold reduction of mature B cells in the spleen

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