All Phenotypes Ankrd2<tm1Krc> MGI Mouse

About Help FAQ

Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Ankrd2^tm1Krc
targeted mutation 1, Kenneth R Chien
MGI:3760784

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ankrd2^tm1Krc/Ankrd2^tm1Krc	involves: 129 * Black Swiss	MGI:5605990
cx2	Ankrd1^tm1Krc/Ankrd1^tm1Krc Ankrd2^tm1Krc/Ankrd2^tm1Krc Ankrd23^tm1Krc/Ankrd23^tm1Krc	involves: 129 * Black Swiss	MGI:3760786

Allelic Composition	Ankrd2^tm1Krc/Ankrd2^tm1Krc
Genetic Background	involves: 129 * Black Swiss

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ankrd2^tm1Krc mutation (0 available); any Ankrd2 mutation (16 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal inflammatory response ( J:214867 )

• expression of pro-inflammatory cytokines is upregulated in differentiated myoblasts

muscle

abnormal skeletal muscle morphology ( J:214867 )

• skeletal muscle appears normal, however the slow twitch-muscle gene expression program is modified, with Il6, Glut4, and Rcan1 downregulated in soleus muscle, indicating that slow muscle fibers are transcripitionally adapted to fiber-type switching toward a faster phenotype

cardiovascular system

cardiovascular system phenotype ( J:215212 )

N	• mice have normal cardiac morphology and physiology

mortality/aging

mortality/aging ( J:215212 )

N	• mice are born at expected Mendelian ratios, are fertile, and survive until adulthood

Allelic Composition	Ankrd1^tm1Krc/Ankrd1^tm1Krc Ankrd2^tm1Krc/Ankrd2^tm1Krc Ankrd23^tm1Krc/Ankrd23^tm1Krc
Genetic Background	involves: 129 * Black Swiss

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ankrd1^tm1Krc mutation (0 available); any Ankrd1 mutation (21 available)
Ankrd23^tm1Krc mutation (0 available); any Ankrd23 mutation (6 available)
Ankrd2^tm1Krc mutation (0 available); any Ankrd2 mutation (16 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

muscle

abnormal sarcomere morphology ( J:125819 )

• sarcomere length at resting is longer than in wild-type mice

• titin lengths in the sarcomere are longer than in wild-type mice

abnormal muscle physiology ( J:125819 )

• muscles exhibit a greater degree of torque loss after eccentric contraction compared to wild-type mice

• however, muscle recovery is normal

cardiovascular system

cardiovascular system phenotype ( J:215212 )

N	• mice exhibit normal cardiac morphology and function and a normal hypertrophic response to transverse aortic constriction

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24