normal phenotype
• mice are born at expected Mendelian ratios, are fertile, and survive until adulthood, have normal cardiac morphology and physiology
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Allele Symbol Allele Name Allele ID |
Ankrd23tm1Krc targeted mutation 1, Kenneth R Chien MGI:3760785 |
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Summary |
2 genotypes
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• mice are born at expected Mendelian ratios, are fertile, and survive until adulthood, have normal cardiac morphology and physiology
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• sarcomere length at resting is longer than in wild-type mice
• titin lengths in the sarcomere are longer than in wild-type mice
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• muscles exhibit a greater degree of torque loss after eccentric contraction compared to wild-type mice
• however, muscle recovery is normal
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N |
• mice exhibit normal cardiac morphology and function and a normal hypertrophic response to transverse aortic constriction
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 12/10/2024 MGI 6.24 |
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