Phenotypes associated with this allele

• Allele Symbol: Grin1^tm1Nak
• Allele Name: targeted mutation 1, Shigetada Nakanishi
• Allele ID: MGI:3760845
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Grin1^tm1Nak/Grin1^tm1Nak	involves: 129S/Sv * C57BL/6 * DBA/2	MGI:3809935

Genotype
MGI:3809935

hm1

• Allelic Composition: Grin1^tm1Nak/Grin1^tm1Nak
• Genetic Background: involves: 129S/Sv * C57BL/6 * DBA/2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:38582 )

• die within a few hours of birth

behavior/neurological

absent gastric milk in neonates ( J:38582 )

abnormal suckling behavior ( J:38582 )

• cannot feed

nervous system

decreased susceptibility to neuronal excitotoxicity ( J:38582 )

• cortical neuronal cells from E15 - E17 fetal mice cultured for 14 - 17 days show no appreciable cell death following short exposures to glutamate or NMDA and are resistant to cell death following prolonged exposure to NMDA

• however, cell death in response to prolonged exposure to glutamate is similar to wild-type controls

abnormal glutamate-mediated receptor currents ( J:38582 )

• cortical neuronal cells from E15 - E17 fetal mice cultured for 12 - 14 days do not show a reduction in glutamate response at hyperpolarizing potentials and complete inhibition of glutamate elicited current by a AMPA/kainate receptor agonist

homeostasis/metabolism

decreased susceptibility to neuronal excitotoxicity ( J:38582 )

• cortical neuronal cells from E15 - E17 fetal mice cultured for 14 - 17 days show no appreciable cell death following short exposures to glutamate or NMDA and are resistant to cell death following prolonged exposure to NMDA

• however, cell death in response to prolonged exposure to glutamate is similar to wild-type controls

cyanosis ( J:38582 )

• develops after birth

cellular

decreased susceptibility to neuronal excitotoxicity ( J:38582 )

• cortical neuronal cells from E15 - E17 fetal mice cultured for 14 - 17 days show no appreciable cell death following short exposures to glutamate or NMDA and are resistant to cell death following prolonged exposure to NMDA

• however, cell death in response to prolonged exposure to glutamate is similar to wild-type controls