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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Rr97tm3Welm
targeted mutation 3, Wilfried Ellmeier
MGI:3761127
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Rr97tm3Welm/Rr97tm3Welm involves: 129 * C57BL/6 MGI:3761135


Genotype
MGI:3761135
hm1
Allelic
Composition		 Rr97tm3Welm/Rr97tm3Welm
Genetic
Background		 involves: 129 * C57BL/6
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See publication links below for author information.
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal CD4-positive T cell differentiation ( J:126027 )
• slight increase of CD4 single positive (SP) cells in thymus
• 15% of these CD4 SP thymocytes show surface expression similar to double positive thymocytes (except lacking CD8 expression)
abnormal CD8-positive, alpha-beta T cell differentiation ( J:126027 )
• there is a small reduction in percentage of CD8 SP thymocytes
abnormal double-positive T cell morphology ( J:126027 )
• there is a small reduction percentage of DP thymocytes
abnormal dendritic cell morphology ( J:126027 )
• there is no change in numbers or percentage of DC that express the CD8alphaalpha homodimer
abnormal gamma-delta intraepithelial T cell morphology ( J:126027 )
• there is no change in numbers or percentage gammadelta IEL that express the CD8alphaalpha homodimer

immune system
abnormal CD4-positive T cell differentiation ( J:126027 )
• slight increase of CD4 single positive (SP) cells in thymus
• 15% of these CD4 SP thymocytes show surface expression similar to double positive thymocytes (except lacking CD8 expression)
abnormal CD8-positive, alpha-beta T cell differentiation ( J:126027 )
• there is a small reduction in percentage of CD8 SP thymocytes
abnormal double-positive T cell morphology ( J:126027 )
• there is a small reduction percentage of DP thymocytes
abnormal dendritic cell morphology ( J:126027 )
• there is no change in numbers or percentage of DC that express the CD8alphaalpha homodimer
abnormal gamma-delta intraepithelial T cell morphology ( J:126027 )
• there is no change in numbers or percentage gammadelta IEL that express the CD8alphaalpha homodimer




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12/10/2024
MGI 6.24 		The Jackson Laboratory