Phenotypes associated with this allele

• Allele Symbol: Tg(MMTV-neu/OT-I/OT-II)CBnel
• Allele Name: transgene insertion C, Brad Nelson
• Allele ID: MGI:3761163
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Tg(MMTV-neu/OT-I/OT-II)CBnel/? Tg(Trp53R172H)8512Jmr/?	involves: C57BL/6 * FVB	MGI:3761175
tg2	Tg(MMTV-neu/OT-I/OT-II)CBnel/?	involves: C57BL/6	MGI:3761174

Genotype
MGI:3761175

cx1

• Allelic Composition: Tg(MMTV-neu/OT-I/OT-II)CBnel/?; Tg(Trp53R172H)8512Jmr/?
• Genetic Background: involves: C57BL/6 * FVB

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased mammary adenocarcinoma incidence ( J:122846 )

• 80% of females develop adencarcinomas by 6-10 months of age; mice generally have 1or two tumors

• tumors are highly mitotic with glandular differentiation in ~30% of cases; ~90% of tumors have minimal necrosis

endocrine/exocrine glands

increased mammary adenocarcinoma incidence ( J:122846 )

• 80% of females develop adencarcinomas by 6-10 months of age; mice generally have 1or two tumors

• tumors are highly mitotic with glandular differentiation in ~30% of cases; ~90% of tumors have minimal necrosis

integument

increased mammary adenocarcinoma incidence ( J:122846 )

• 80% of females develop adencarcinomas by 6-10 months of age; mice generally have 1or two tumors

• tumors are highly mitotic with glandular differentiation in ~30% of cases; ~90% of tumors have minimal necrosis

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
breast cancer		DOID:1612	OMIM:114480	J:122846

Genotype
MGI:3761174

tg2

• Allelic Composition: Tg(MMTV-neu/OT-I/OT-II)CBnel/?
• Genetic Background: involves: C57BL/6

neoplasm

increased mammary gland tumor incidence ( J:122846 )

• only ~50% of females develop mammary tumors by 16 months of age

increased lung tumor incidence ( J:122846 )

• ~37% of mammary tumor-bearing mice frequently have lung metastases consisting of >1mm tumor cell emboli growing within blood vessels

endocrine/exocrine glands

increased mammary gland tumor incidence ( J:122846 )

• only ~50% of females develop mammary tumors by 16 months of age

integument

increased mammary gland tumor incidence ( J:122846 )

• only ~50% of females develop mammary tumors by 16 months of age

respiratory system

increased lung tumor incidence ( J:122846 )

• ~37% of mammary tumor-bearing mice frequently have lung metastases consisting of >1mm tumor cell emboli growing within blood vessels

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
breast cancer		DOID:1612	OMIM:114480	J:122846