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Allele Symbol Allele Name Allele ID |
Tg(Tcra5CC7,Tcrb5CC7)IWep transgene insertion I, William E Paul MGI:3761187 |
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| Summary |
6 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• T cells expressing the transgenic MHC class II-restricted TCR show diversion from the CD4+ lineage to the CD8+ lineage
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• T cells expressing the transgenic MHC class II-restricted TCR show diversion from the CD4+ lineage to the CD8+ lineage
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• when stimulated with low concentrations of antigen, CD4 T cells differentiate predominately into a Th1 phenotype while controls develop into a Th2 phenotype
• these T cells have increased expression of the T-bet transcription factor
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• T cells cultured under Th1 polarizing conditions produce less IFN-gamma than controls
• Th1 T cells produce 1.5- to 200-fold less IFN-gamma than controls
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• T cells cultured under Th2 polarizing conditions produce less IL-10 than controls
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• T cells cultured under Th2 polarizing conditions produce less IL-4 than controls
• Th2 T cells produce 3.5- to 300-fold less IL-4 than controls
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• T cells cultured under Th2 polarizing conditions produce less IL-5 than controls
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• when stimulated with low concentrations of antigen, CD4 T cells differentiate predominately into a Th1 phenotype while controls develop into a Th2 phenotype
• these T cells have increased expression of the T-bet transcription factor
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• the percentages and absolute numbers of CD4+ single positive thymocytes is drastically reduced compared to wild-type and transgenic controls
• peripheral CD4 T cell numbers are also reduced
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• the percentages and absolute numbers of CD4+ single positive thymocytes is drastically reduced compared to wild-type and transgenic controls
• peripheral CD4 T cell numbers are also reduced
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• decreased proportion of IFN-gamma-producing cells in draining lymph nodes after adoptive transfer nae T cells
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• increase in the percentage of IL-17-producing cells in culturing CD4+ T cells in vitro under Th17-polarizing conditions
• produce more than twice as many Th17 cells in draining lymph nodes after adoptive transfer naive T cells
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• decreased proportion of IFN-gamma-producing cells in draining lymph nodes after adoptive transfer nae T cells
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• increase in the percentage of IL-17-producing cells in culturing CD4+ T cells in vitro under Th17-polarizing conditions
• produce more than twice as many Th17 cells in draining lymph nodes after adoptive transfer naive T cells
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• an increase in double positive thymocytes results from arrested thymocyte development
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• there is a complete block in CD4 single-positive thymocyte development
• the minor CD8 single-positive population in transgenic mice is also significantly affected
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• an increase in double positive thymocytes results from arrested thymocyte development
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• there is a complete block in CD4 single-positive thymocyte development
• the minor CD8 single-positive population in transgenic mice is also significantly affected
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• CD4 T cells become activated when cultured with MCC peptide, HEL protein and B cells from Tg(IghelMD4)4Ccg transgenic mice
• CD4 T cell and B cell co-culturing with MCC peptide but not HEL protein induces a modest T cell activation
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• CD4 T cells become activated when cultured with MCC peptide, HEL protein and B cells from Tg(IghelMD4)4Ccg transgenic mice
• CD4 T cell and B cell co-culturing with MCC peptide but not HEL protein induces a modest T cell activation
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 06/12/2024 MGI 6.13 |
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