immune system
• T cells are almost completely unresponsive to AC11- and PHA-induced proliferation
|
• thymi display structurally abnormal cortices
|
• thymi lack discernible medullas
|
small thymus
(
J:126456
)
• mice have little or no thymus
|
• T cell number is reduced by 20-fold
|
• CD4-CD8- double negative cells are decreased by 62% of levels in Tg(CD2-Myb/en)2Kmw homozygotes
|
• the number of CD8+ single negative by 4-fold compared to in wild-type mice
|
small spleen
(
J:126456
)
• mice have spleens that are between a half to a quarter the size of those in wild-type mice
• mice have little or no thymus
|
hematopoietic system
• T cells are almost completely unresponsive to AC11- and PHA-induced proliferation
|
• thymi display structurally abnormal cortices
|
• thymi lack discernible medullas
|
small thymus
(
J:126456
)
• mice have little or no thymus
|
• T cell number is reduced by 20-fold
|
• CD4-CD8- double negative cells are decreased by 62% of levels in Tg(CD2-Myb/en)2Kmw homozygotes
|
• the number of CD8+ single negative by 4-fold compared to in wild-type mice
|
small spleen
(
J:126456
)
• mice have spleens that are between a half to a quarter the size of those in wild-type mice
• mice have little or no thymus
|
endocrine/exocrine glands
• thymi display structurally abnormal cortices
|
• thymi lack discernible medullas
|
small thymus
(
J:126456
)
• mice have little or no thymus
|
cellular
• T cells are almost completely unresponsive to AC11- and PHA-induced proliferation
|