Phenotypes associated with this allele

• Allele Symbol: Tg(CD2-Myb/en)2Kmw
• Allele Name: transgene insertion 2, Kathleen Mary Weston
• Allele ID: MGI:3761384
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
tg1	Tg(CD2-Myb/en)2Kmw/Tg(CD2-Myb/en)2Kmw	involves: C57BL/10 * CBA	MGI:3761388
tg2	Tg(CD2-Myb/en)2Kmw/?	involves: C57BL/10 * CBA	MGI:3761387

Genotype
MGI:3761388

tg1

• Allelic Composition: Tg(CD2-Myb/en)2Kmw/Tg(CD2-Myb/en)2Kmw
• Genetic Background: involves: C57BL/10 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:126456 )

• mice die prior to 6 months of age from disseminated infections

immune system

decreased T cell proliferation ( J:126456 )

• T cells are almost completely unresponsive to AC11- and PHA-induced proliferation

small thymus ( J:126456 )

• mice have little or no thymus

increased double-negative T cell number ( J:126456 )

• the percent of double negative cells is increased

• the percent of CD3- and CD3^low double negative cells is increased especially in homozygotes

decreased T cell number ( J:126456 )

• T cell number is reduced by 20-fold

decreased double-positive T cell number ( J:126456 )

• double positive cells only comprise 35% of the population compared to 70% to 80% in wild-type mice

small spleen ( J:126456 )

• mice have spleens that are between a half to a quarter the size of those in wild-type mice

growth/size/body

decreased body size ( J:126456 )

• mice are runted

hematopoietic system

decreased T cell proliferation ( J:126456 )

• T cells are almost completely unresponsive to AC11- and PHA-induced proliferation

small thymus ( J:126456 )

• mice have little or no thymus

increased double-negative T cell number ( J:126456 )

• the percent of double negative cells is increased

• the percent of CD3- and CD3^low double negative cells is increased especially in homozygotes

decreased T cell number ( J:126456 )

• T cell number is reduced by 20-fold

decreased double-positive T cell number ( J:126456 )

• double positive cells only comprise 35% of the population compared to 70% to 80% in wild-type mice

small spleen ( J:126456 )

• mice have spleens that are between a half to a quarter the size of those in wild-type mice

endocrine/exocrine glands

small thymus ( J:126456 )

• mice have little or no thymus

cellular

decreased T cell proliferation ( J:126456 )

• T cells are almost completely unresponsive to AC11- and PHA-induced proliferation

Genotype
MGI:3761387

tg2

• Allelic Composition: Tg(CD2-Myb/en)2Kmw/?
• Genetic Background: involves: C57BL/10 * CBA

immune system

decreased T cell proliferation ( J:126456 )

• T cell proliferation induced by 2C11 is reduced by 50%

• T cell proliferation induced by PHA is reduced to 68% of wild-type mice

increased double-negative T cell number ( J:126456 )

• the percent of CD3- and CD3^low double negative cells is increased especially in homozygotes

decreased T cell number ( J:126456 )

• T cell number is reduced by 2- to 4-fold

abnormal single-positive T cell number ( J:126456 )

• mice exhibit a reduction in the ratio of CD4+ to CD8+ single positive cells compared to wild-type mice

• however, the number of double positive cells is unaffected

hematopoietic system

decreased T cell proliferation ( J:126456 )

• T cell proliferation induced by 2C11 is reduced by 50%

• T cell proliferation induced by PHA is reduced to 68% of wild-type mice

increased double-negative T cell number ( J:126456 )

• the percent of CD3- and CD3^low double negative cells is increased especially in homozygotes

decreased T cell number ( J:126456 )

• T cell number is reduced by 2- to 4-fold

abnormal single-positive T cell number ( J:126456 )

• mice exhibit a reduction in the ratio of CD4+ to CD8+ single positive cells compared to wild-type mice

• however, the number of double positive cells is unaffected

cellular

decreased T cell proliferation ( J:126456 )

• T cell proliferation induced by 2C11 is reduced by 50%

• T cell proliferation induced by PHA is reduced to 68% of wild-type mice